ArticlePloS one2012
Delta-like ligand (DLL)1 expression in early mouse decidua and its localization to uterine natural killer cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Vascular changes in the cycling and early pregnant uterus.JCI insight · 2023Review
- Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
- Transcriptome, Spliceosome and Editome Expression Patterns of the Porcine Endometrium in Response to a Single Subclinical Dose ofInternational journal of molecular sciences · 2020Article
- Misoprostol-Induced Modification of the Notch Signaling Pathway in the Human Cervix.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy.PloS one · 2019Article
- Notch Signaling in Inflammation-Induced Preterm Labor.Scientific reports · 2015Article
- Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface.Journal of visualized experiments : JoVE · 2015Article
- Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation.Frontiers in immunology · 2015Article
- Leukocyte driven-decidual angiogenesis in early pregnancy.Cellular & molecular immunology · 2014Review
- Ly49 receptors activate angiogenic mouse DBA⁺ uterine natural killer cells.Cellular & molecular immunology · 2014Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice.Placenta · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Uterine vascular changes, critical for pregnancy success, occur at each implant site during endometrial decidualization. Mesometrial decidualization recruits high numbers of angiogenic, uterine Natural Killer (uNK) cells that trigger midpregnancy spiral arterial remodeling. We postulated that uNK cells contribute to early decidual angiogenesis as endothelial-cell extrinsic sources of Delta-like ligand 1 (DLL1), a molecule that induces endothelial tip cell differentiation and orthogonal vascular growth in other tissues. Virgin uteri expressed Dll1 mesometrially and anti-mesometrially and relative expression increased in both anatomic regions as pregnancy progressed. Analyses of transcripts from gd10.5 uNK cells flow sorted on the basis of expression of Dolichos biflorus agglutinin (DBA) lectin revealed that DBA+ but not DBA- uNK cells expressed Dll1. Immunostaining at gd4.5 found DLL1-expressing cells rare. At gd6.5, DBA+ uNK cells at all stages of maturation expressed DLL1. By gd10.5, DLL1 immunoreactivity was strongly expressed by some but not all DBA+ uNK cells and more weakly by DBA- cells. DLL1+ cells were mesometrially stratified and concentrated within central decidua basalis. Our data suggest that uNK cells have the potential to induce endothelial tip cell differentiation and to promote non-planar vascular growth within early decidua basalis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.