ArticlePloS one2012
Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 5 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The Role of OPathology oncology research : POR · 2020Pooled it
- Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility.BMC cancer · 2018Pooled it
- GSTM1 and GSTT1 polymorphisms are associated with increased bladder cancer risk: Evidence from updated meta-analysis.Oncotarget · 2017Pooled it
- Pooled it
- MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies.PloS one · 2013Pooled it
- Detecting Interactions in High-Dimensional Data Using Cross Leverage Scores.Biometrical journal. Biometrische Zeitschrift · 2024Article
- Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus.Scientific reports · 2021Article
- DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers.International journal of molecular sciences · 2020Review
- Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size.Translational andrology and urology · 2020Article
- Relationship between Telomere Length, Genetic Traits and Environmental/Occupational Exposures in Bladder Cancer Risk by Structural Equation Modelling.International journal of environmental research and public health · 2017Article
- Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer.Carcinogenesis · 2017Article
- Additional evidence for the 'wimp SNP' concept of carcinogenesis.EXCLI journal · 2017Article
- Discovering urinary bladder cancer risk variants: Status quo after almost ten years of genome-wide association studies.EXCLI journal · 2017Article
- Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk.Molecular cancer research : MCR · 2016Article
- The association between rs9642880 gene polymorphism and bladder cancer risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Effects of PSCA rs2294008 (C/T) and c-MYC rs9642880 (G/T) polymorphisms on bladder cancer: evidence from a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Correction: Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers.PloS one · 2015Article
- A combination of single nucleotide polymorphisms in the 3'untranslated region of HLA-G is associated with preeclampsia.Human immunology · 2014Article
- Impact of urinary bladder cancer risk variants on prognosis and survival.EXCLI journal · 2014Article
- The post GWAS era: strategies to identify gene-gene and gene-environment interactions in urinary bladder cancer.EXCLI journal · 2014Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, genome-wide association studies have identified and validated genetic variations associated with urinary bladder cancer (UBC). However, it is still unknown whether the high-risk alleles of several SNPs interact with one another, leading to an even higher disease risk. Additionally, there is no information available on how the UBC risk due to these SNPs compare to the risk of cigarette smoking and to occupational exposure to urinary bladder carcinogens, and whether the same or different SNP combinations are relevant in smokers and non-smokers. To address these questions, we analyzed the genotypes of six SNPs, previously found to be associated with UBC, together with the GSTM1 deletion, in 1,595 UBC cases and 1,760 controls, stratified for smoking habits. We identified the strongest interactions of different orders and tested the stability of their effect by bootstrapping. We found that different SNP combinations were relevant in smokers and non-smokers. In smokers, polymorphisms involved in detoxification of cigarette smoke carcinogens were most relevant (GSTM1, rs11892031), in contrast to those in non-smokers with MYC and APOBEC3A near polymorphisms (rs9642880, rs1014971) being the most influential. Stable combinations of up to three high-risk alleles resulted in higher odds ratios (OR) than the individual SNPs, although the interaction effect was less than additive. The highest stable combination effects resulted in an OR of about 2.0, which is still lower than the ORs of cigarette smoking (here, current smokers' OR: 3.28) and comparable to occupational carcinogen exposure risks which, depending on the workplace, show mostly ORs up to 2.0.
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