ArticlePloS one2012
APOE status modulates the changes in network connectivity induced by brain stimulation in non-demented elders.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- A Systematic Review of Non-invasive Brain Stimulation Applications to Memory in Healthy Aging.Frontiers in neurology · 2020Pooled it
- How Can Transcranial Magnetic Stimulation Be Used to Modulate Episodic Memory?: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2019Pooled it
- Trial
- The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Identification of Cortical Targets for Modulating Function Supported by the Human Hippocampal Network.Human brain mapping · 2025Article
- A new index of cortical plasticity induced by paired associative stimulation to describe cognitive status in aged healthy subjects.Frontiers in physiology · 2025Article
- Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Leveraging technology to personalize cognitive enhancement methods in aging.Nature aging · 2022Article
- Article
- Biomarkers Obtained by Transcranial Magnetic Stimulation in Neurodevelopmental Disorders.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2022Article
- Repetitive Transcranial Magnetic Stimulation as a Treatment for Veterans with Cognitive Impairment and Multiple Comorbidities.Journal of Alzheimer's disease : JAD · 2022Article
- Protocols for cognitive enhancement. A user manual for Brain Health Services-part 5 of 6.Alzheimer's research & therapy · 2021Article
- Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- High-frequency transcranial magnetic stimulation protects APP/PS1 mice against Alzheimer's disease progress by reducing APOE and enhancing autophagy.Brain and behavior · 2020Article
- Repetitive Transcranial Magnetic Stimulation Improved Source Memory and Modulated Recollection-Based Retrieval in Healthy Older Adults.Frontiers in psychology · 2020Article
- Determinants of Inter-Individual Variability in Corticomotor Excitability Induced by Paired Associative Stimulation.Frontiers in neuroscience · 2019Article
- Test-Retest Reliability of the Effects of Continuous Theta-Burst Stimulation.Frontiers in neuroscience · 2019Article
- Transcranial magnetic stimulation intervention in Alzheimer's disease: a research proposal for a randomized controlled trial.BMC research notes · 2018Article
- The effect of tDCS on functional connectivity in primary progressive aphasia.NeuroImage. Clinical · 2018Article
- Interindividual variability in response to continuous theta-burst stimulation in healthy adults.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a critical role in such adaptation. We induced a controlled brain disruption using repetitive transcranial magnetic stimulation (rTMS) and show that APOE status determines its impact on distributed brain networks as assessed by functional MRI (fMRI).Twenty non-demented elders exhibiting mild memory dysfunction underwent two fMRI studies during face-name encoding tasks (before and after rTMS). Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas. APOE ε4 bearers exhibited this pattern in two separate independent components, whereas ε4-non carriers presented a single partially overlapping network. Following rTMS all subjects showed slight ameliorations in memory performance, regardless of APOE status. However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation. Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS.Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.