Evidence map›Paper›PMID 23284744›Full record

ArticlePloS one2012

StRAP: an integrated resource for profiling high-throughput cancer genomic data from stress response studies.

Seth Johnson, Biju Issac, Shuping Zhao, Mohit Bisht, Orieta Celiku, Philip Tofilon, Kevin Camphausen, Uma Shankavaram

Abstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seth JohnsonRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Biju Issac
Shuping Zhao
Mohit Bisht
Orieta Celiku
Philip Tofilon
Kevin Camphausen
Uma Shankavaram

Funding

Intramural NIH HHS
6 · The paper itself

Abstract

The increasing availability and maturity of DNA microarray technology has led to an explosion of cancer profiling studies for identifying cancer biomarkers, and predicting treatment response. Uncovering complex relationships, however, remains the most challenging task as it requires compiling and efficiently querying data from various sources. Here, we describe the Stress Response Array Profiler (StRAP), an open-source, web-based resource for storage, profiling, visualization, and sharing of cancer genomic data. StRAP houses multi-cancer microarray data with major emphasis on radiotherapy studies, and takes a systems biology approach towards the integration, comparison, and cross-validation of multiple cancer profiling studies. The database is a comprehensive platform for comparative analysis of gene expression data. For effective use of arrays, we provide user-friendly and interactive visualization tools that can display the data and query results. StRAP is web-based, platform-independent, and freely accessible at http://strap.nci.nih.gov/.

Indexed as

Database Management SystemsGene Expression ProfilingGenomicsSoftwareBiomarkers, TumorHigh-Throughput Nucleotide SequencingHumansNeoplasmsOligonucleotide Array Sequence AnalysisStress, PhysiologicalBiomarkers, Tumor

Identifiers

PMID23284744
PMCPMC3524254

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.