Evidence map›Paper›PMID 23284714›Full record

ArticlePloS one2012

Living the good life? Mortality and hospital utilization patterns in the Old Order Amish.

Braxton D Mitchell, Woei-Jyh Lee, Magdalena I Tolea, Kelsey Shields, Zahra Ashktorab, Laurence S Magder, Kathleen A Ryan, Toni I Pollin, Patrick F McArdle, Alan R Shuldiner and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Exonic Variation and Its Clinical Impact in 7221 Old Order Amish.American journal of medical genetics. Part A · 2025
    Article
  4. Review
  5. Genetic versus stress and mood determinants of sleep in the Amish.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021
    Article
  6. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Daily and Seasonal Variation in Light Exposure among the Old Order Amish.International journal of environmental research and public health · 2020
    Article
  11. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Braxton D MitchellDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. bmitchel@medicine.umaryland.edu
Woei-Jyh Lee
Magdalena I Tolea
Kelsey Shields
Zahra Ashktorab
Laurence S Magder
Kathleen A Ryan
Toni I Pollin
Patrick F McArdle
Alan R Shuldiner
Alejandro A Schäffer
University of Maryland, Baltimore · USNational Institutes of Health · USNational Center for Biotechnology Information · USUnited States Department of Veterans Affairs · US

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Genome-wide Search for CVD Gene-Environment InteractionsU01HL072515 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2002 to 2008
$11.2M
GENETICS OF DIABETES IN THE AMISHR01DK054261 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2000 to 2009
$5.1M
Case Studies In GeneticsZIALM000097 · NLM · NATIONAL LIBRARY OF MEDICINE · PI SCHAFFER, ALEJANDRO A · 2009 to 2019
$4.6M
Longevity Genes in Founder PopulationsR01AG018728 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2001 to 2005
$3.8M
Genetic Influences on Coronary Artery CalcificationR01HL088119 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2007 to 2010
$2.8M
GENETICS OF OSTEOPOROSIS IN THE AMISHR01AR046838 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2000 to 2004
$2.7M
Joint Determinants of Bone Density and CVD CalcificationR01HL069313 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2001 to 2004
$1.4M
Intramural NIH HHSNHLBI NIH HHS R01 HL069313NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL69313NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL72515NIAMS NIH HHS R01 AR046838NIA NIH HHS R01 AG1872801NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK054261NIDDK NIH HHS R01 DK54261
6 · The paper itself

Abstract

Lifespan increases observed in the United States and elsewhere throughout the developed world, have been attributed in part to improvements in medical care access and technology and to healthier lifestyles. To differentiate the relative contributions of these two factors, we have compared lifespan in the Old Order Amish (OOA), a population with historically low use of medical care, with that of Caucasian participants from the Framingham Heart Study (FHS), focusing on individuals who have reached at least age 30 years.Analyses were based on 2,108 OOA individuals from the Lancaster County, PA community born between 1890 and 1921 and 5,079 FHS participants born approximately the same time. Vital status was ascertained on 96.9% of the OOA cohort through 2011 and through systematic follow-up of the FHS cohort. The lifespan part of the study included an enlargement of the Anabaptist Genealogy Database to 539,822 individuals, which will be of use in other studies of the Amish. Mortality comparisons revealed that OOA men experienced better longevity (p<0.001) and OOA women comparable longevity than their FHS counterparts.We further documented all OOA hospital discharges in Lancaster County, PA during 2002-2004 and compared OOA discharge rates to Caucasian national rates obtained from the National Hospital Discharge Survey for the same time period. Both OOA men and women experienced markedly lower rates of hospital discharges than their non-Amish counterparts, despite the increased lifespan.We speculate that lifestyle factors may predispose the OOA to greater longevity and perhaps to lesser hospital use. Identifying these factors, which might include behaviors such as lesser tobacco use, greater physical activity, and/or enhanced community assimilation, and assessing their transferability to non-Amish communities may produce significant gains to the public health.

Indexed as

LongevityAdultAgedAged, 80 and overAmishCohort StudiesFemaleHospitals, GeneralHumansLength of StayLife StyleMaleMiddle AgedMortalityProtestantismSurvival Rate

Identifiers

PMID23284714
PMCPMC3526600
OpenAlexW2153564718

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.