SynthesisPloS one2012
Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association of Preadmission Statin Use and Mortality in Critically Ill Patients: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Rosuvastatin for sepsis-associated acute respiratory distress syndrome.The New England journal of medicine · 2014Trial
- Statins, Allies against Antibiotic Resistance?Current medicinal chemistry · 2025Review
- Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate.American journal of physiology. Endocrinology and metabolism · 2024Article
- Repositioning of HMG-CoA Reductase Inhibitors as Adjuvants in the Modulation of Efflux Pump-Mediated Bacterial and Tumor Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Treating COVID-19: Targeting the Host Response, Not the Virus.Life (Basel, Switzerland) · 2023Review
- Statins and SARS-CoV-2 Infection: Results of a Population-Based Prospective Cohort Study of 469 749 Adults From 2 Canadian Provinces.Journal of the American Heart Association · 2021Article
- Statin use is associated with lower disease severity in COVID-19 infection.Scientific reports · 2020Article
- Statins in coronavirus outbreak: It's time for experimental and clinical studies.Pharmacological research · 2020Article
- Statins and outcomes of hospitalized patients with laboratory-confirmed 2017-2018 influenza.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Hyperlipidemia, statin use and dengue severity.Scientific reports · 2018Article
- Optimal duration for continuation of statin therapy in bacteremic patients.Therapeutic advances in infectious disease · 2018Article
- The host response in critically ill sepsis patients on statin therapy: a prospective observational study.Annals of intensive care · 2018Article
- Improved survival with continuation of statins in bacteremic patients.SAGE open medicine · 2018Article
- Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia.Antimicrobial agents and chemotherapy · 2017Article
- Is There Potential for Repurposing Statins as Novel Antimicrobials?Antimicrobial agents and chemotherapy · 2016Review
- Molecular mechanisms of Ebola virus pathogenesis: focus on cell death.Cell death and differentiation · 2015Review
- The association between donor and recipient statin use and infections after allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2015Article
- Atorvastatin Reduces the Survival of Candida albicans-Infected BALB/c Mice.Frontiers in microbiology · 2015Article
- Impact of prior statin therapy on the outcome of patients with suspected ventilator-associated pneumonia: an observational study.Critical care (London, England) · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo update and refine systematic literature review on the association between outpatient statins use and mortality in patients with infectious disease. MATERIALS AND
methodsWe searched articles published before September 31, 2012, on the association between statins and infectious disease-related mortality through electronic databases. Eligible articles were analyzed in Review Manager 5.1. We conducted stratification analysis by study design, infection types, clinical outcomes and study locations.
resultsThe pooled odds ratio (OR) for death (statins use vs. no use) across the 41 included studies was 0.71 (95% confidence interval: 0.64, 0.78). The corresponding pooled ORs were 0.58 (0.38, 0.90), 0.66 (0.57, 0.75), 0.71 (0.57, 0.89) and 0.83 (0.67, 1.04) for the case-control study, retrospective cohort studies, prospective cohort studies and RCTs; 0.40 (0.20, 0.78), 0.61 (0.41, 0.90), 0.69 (0.62, 0.78) and 0.86 (0.68, 1.09) for bacteremia, sepsis, pneumonia and other infections; 0.62 (0.534, 0.72), 0.68 (0.53, 0.89), 0.71 (0.61, 0.83) and 0.86 (0.70, 1.07) for 30-day, 90-day, in-hospital and long-term (>1 year) mortality, respectively.
conclusionsOutpatient statins use is associated with a lower risk of death in patients with infectious disease in observational studies, but in a less extent in clinical trials. This association also varies considerably by infection types and clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.