ArticlePloS one2012
Androgens regulate gene expression in avian skeletal muscles.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Genome assembly of the foot-flagging frog, Staurois parvus: a resource for understanding mechanisms of behavior.G3 (Bethesda, Md.) · 2023Article
- Article
- The Effects of Tetrapeptides Designed to Fit the Androgen Binding Site of ZIP9 on Myogenic and Osteogenic Cells.Biology · 2021Article
- Sex Steroids as Regulators of Gestural Communication.Endocrinology · 2020Review
- 3β-HSD expression in the CNS of a manakin and finch.General and comparative endocrinology · 2018Article
- Insight into the neuroendocrine basis of signal evolution: a case study in foot-flagging frogs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Across sex and age: Learning and memory and patterns of avian hippocampal gene expression.Behavioral neuroscience · 2017Article
- Dissociable Effects on Birdsong of Androgen Signaling in Cortex-Like Brain Regions of Canaries.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sex differences in neuromuscular androgen receptor expression and sociosexual behavior in a sex changing fish.PloS one · 2017Article
- Increased androgenic sensitivity in the hind limb muscular system marks the evolution of a derived gestural display.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Time-dependent gene expression analysis after mouse skeletal muscle contusion.Journal of sport and health science · 2016Article
- Research Resource: Hormones, Genes, and Athleticism: Effect of Androgens on the Avian Muscular Transcriptome.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Expression of 5α- and 5β-reductase in spinal cord and muscle of birds with different courtship repertoires.Frontiers in zoology · 2016Article
- Evolutionary patterns of adaptive acrobatics and physical performance predict expression profiles of androgen receptor - but not oestrogen receptor - in the forelimb musculature.Functional ecology · 2015Article
- Behavioral effects of social challenges and genomic mechanisms of social priming: What's testosterone got to do with it?Current zoology · 2014Article
- Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird.The Journal of experimental biology · 2014Article
- Seasonal variation in pectoralis muscle and heart myostatin and tolloid-like proteinases in small birds: a regulatory role for seasonal phenotypic flexibility?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Synergistic effect of fadrozole and insulin-like growth factor-I on female-to-male sex reversal and body weight of broiler chicks.PloS one · 2014Article
- Peripheral androgen receptors sustain the acrobatics and fine motor skill of elaborate male courtship.Endocrinology · 2013Article
- Hormones and the neuromuscular control of courtship in the golden-collared manakin (Manacus vitellinus).Frontiers in neuroendocrinology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Circulating androgens in adult reproductively active male vertebrates influence a diversity of organ systems and thus are considered costly. Recently, we obtained evidence that androgen receptors (AR) are expressed in several skeletal muscles of three passeriform birds, the golden-collared manakin (Manacus vitellinus), zebra finch (Taenopygia guttata), and ochre-bellied flycatcher (Mionectes oleagieus). Because skeletal muscles that control wing movement make up the bulk of a bird's body mass, evidence for widespread effects of androgen action on these muscles would greatly expand the functional impact of androgens beyond their well-characterized effects on relatively discrete targets throughout the avian body. To investigate this issue, we use quantitative PCR (qPCR) to determine if androgens alter gene mRNA expression patterns in wing musculature of wild golden-collared manakins and captive zebra finches. In manakins, the androgen testosterone (T) up-regulated expression of parvalbumin (PV) and insulin-like growth factor I (IGF-I), two genes whose products enhance cellular Ca(2+) cycling and hypertrophy of skeletal muscle fibers. In T-treated zebra finches, the anti-androgen flutamide blunted PV and IGF-I expression. These results suggest that certain transcriptional effects of androgen action via AR are conserved in passerine skeletal muscle tissue. When we examined wing muscles of manakins, zebra finches and ochre-bellied flycatchers, we found that expression of PV and IGF-I varied across species and in a manner consistent with a function for AR-dependent gene regulation. Together, these findings imply that androgens have the potential to act on avian muscle in a way that may enhance the physicality required for successful reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.