ArticlePloS one2012
Synergistic effects of serum uric acid and cardiometabolic risk factors on early stage atherosclerosis: the cardiometabolic risk in Chinese study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study.Cardiovascular diabetology · 2014Trial
- Predictive value of serum chitinase 3-like 1 for dysfunctional autogenous arteriovenous fistulas in patients with chronic kidney disease stage G5.Clinics (Sao Paulo, Brazil) · 2025Article
- Inflammaging and Vascular Function in Metabolic Syndrome: The Role of Hyperuricemia.Medicina (Kaunas, Lithuania) · 2022Article
- Evaluation of the associations of body height with blood pressure and early-stage atherosclerosis in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study.Scientific reports · 2020Article
- Uric Acid and Arterial Stiffness.Therapeutics and clinical risk management · 2020Review
- Article
- Peripheral arterial stiffness is associated with higher baseline plasma uric acid: A prospective cohort study.Saudi journal of biological sciences · 2017Article
- Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study.Internal and emergency medicine · 2016Article
- Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study.American journal of hypertension · 2015Article
- Elevated Blood Urea Nitrogen is Associated With Critical Limb Ischemia in Peripheral Arterial Disease Patients.Medicine · 2015Article
- Adiponectin Genotype, Blood Pressures, and Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Neck circumference and prehypertension: the cardiometabolic risk in Chinese study.Journal of hypertension · 2015Article
- Article
- Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study.Diabetology & metabolic syndrome · 2014Article
- Serum uric Acid is not an independent risk factor for premature coronary artery disease.Cardiorenal medicine · 2013Article
- Uric Acid - key ingredient in the recipe for cardiorenal metabolic syndrome.Cardiorenal medicine · 2013Review
- Heart rate and the cardiometabolic risk.Current hypertension reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo comprehensively examine the associations of serum uric acid (SUA) with central and peripheral arterial stiffness in Chinese adults, and particularly assess the interactions between SUA and other cardiometabolic risk factors.
methodsThe study included 3,772 Chinese men and women with carotid radial pulse wave velocity (crPWV), carotid femoral PWV (cfPWV), carotid artery dorsalis pedis PWV (cdPWV) and SUA measured.
resultsAfter adjustment for age, sex, and BMI, the levels of SUA were significantly associated with increasing trend of cfPWV, crPWV and cdPWV (P for trend <0.0001). Further adjustment for heart rate (HR), blood pressure (BP) and lipids attenuated the associations with crPWV and cdPWV to be non-significant (P = 0.1, P = 0.099 respectively), but the association between SUV and cfPWV remained significant (P = 0.004). We found significant interactions between SUA and HR or BP in relation to cfPWV (P for interaction = 0.03, 0.003 respectively). The associations between SUA and cfPWV were more evident among individuals with higher HR or normal BP than those with lower HR or hypertension.
conclusionsSUA was associated with elevated aortic arterial stiffness in Chinese adults, independent of conventional cardiovascular risk factors. BP and HR might modify the deleterious effects of SUA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.