ArticlePLoS genetics2012
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A.PLoS genetics · 2026Article
- Association of DNA methyltransferase polymorphisms with breast cancer: a nested case‒control study of the Arkansas Rural Community Health study.BMC cancer · 2026Article
- TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.Nature communications · 2023Article
- Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1.Communications biology · 2022Article
- Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.Life science alliance · 2021Article
- Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.Frontiers in immunology · 2021Article
- DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy.Cancers · 2020Review
- The microbiota programs DNA methylation to control intestinal homeostasis and inflammation.Nature microbiology · 2020Article
- Molecular Mechanisms Underlying the Link between Diet and DNA Methylation.International journal of molecular sciences · 2018Review
- Epigenetic Changes Associated with Early Life Experiences: Saliva, A Biospecimen for DNA Methylation Signatures.Current genomics · 2018Article
- Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation.Blood advances · 2018Article
- Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.Blood cells, molecules & diseases · 2018Article
- The DNA methyltransferase family: a versatile toolkit for epigenetic regulation.Nature reviews. Genetics · 2018Review
- Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero.Respiratory research · 2017Article
- The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.Oncotarget · 2017Article
- Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas.Melanoma research · 2017Article
- Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.Molecular and cellular biology · 2016Article
- Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Cell discovery · 2016Article
- Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.Oncogene · 2015Article
- DNMT3A in haematological malignancies.Nature reviews. Cancer · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Changes in genomic DNA methylation patterns are generally assumed to play an important role in the etiology of human cancers. The Dnmt3a enzyme is required for the establishment of normal methylation patterns, and mutations in Dnmt3a have been described in leukemias. Deletion of Dnmt3a in a K-ras-dependent mouse lung cancer model has been shown to promote tumor progression, which suggested that the enzyme might suppress tumor development by stabilizing DNA methylation patterns. We have used whole-genome bisulfite sequencing to comprehensively characterize the methylomes from Dnmt3a wildtype and Dnmt3a-deficient mouse lung tumors. Our results show that profound global methylation changes can occur in K-ras-induced lung cancer. Dnmt3a wild-type tumors were characterized by large hypomethylated domains that correspond to nuclear lamina-associated domains. In contrast, Dnmt3a-deficient tumors showed a uniformly hypomethylated genome. Further data analysis revealed that Dnmt3a is required for efficient maintenance methylation of active chromosome domains and that Dnmt3a-deficient tumors show moderate levels of gene deregulation in these domains. In summary, our results uncover conserved features of cancer methylomes and define the role of Dnmt3a in maintaining DNA methylation patterns in cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.