ArticlePLoS genetics2012
Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
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- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- N-Myc downstream regulated gene 1b is a regulator of cell adhesion during early muscle development.bioRxiv : the preprint server for biology · 2025Article
- Circadian Rhythms of Locomotor Activity Mediated byInsects · 2023Article
- A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.International journal of molecular sciences · 2022Article
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- Identification of Rhythmically Expressed LncRNAs in the Zebrafish Pineal Gland and Testis.International journal of molecular sciences · 2021Article
- Repeated evolution of circadian clock dysregulation in cavefish populations.PLoS genetics · 2021Article
- Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina.Journal of pineal research · 2020Article
- Developmental exposure to PbChemosphere · 2020Article
- Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System.Current biology : CB · 2019Article
- Single Cell Sequencing of the Pineal Gland: The Next Chapter.Frontiers in endocrinology · 2019Review
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- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons.Molecular neurobiology · 2017Article
- Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish.Scientific reports · 2017Article
- Article
- The Hypocretin/Orexin Neuronal Networks in Zebrafish.Current topics in behavioral neurosciences · 2017Review
- Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.PLoS genetics · 2016Article
- Identifying Novel Transcriptional Regulators with Circadian Expression.Molecular and cellular biology · 2016Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of biochemical, physiological, and molecular processes are known to have daily rhythms driven by an endogenous circadian clock. While extensive research has greatly improved our understanding of the molecular mechanisms that constitute the circadian clock, the links between this clock and dependent processes have remained elusive. To address this gap in our knowledge, we have used RNA sequencing (RNA-seq) and DNA microarrays to systematically identify clock-controlled genes in the zebrafish pineal gland. In addition to a comprehensive view of the expression pattern of known clock components within this master clock tissue, this approach has revealed novel potential elements of the circadian timing system. We have implicated one rhythmically expressed gene, camk1gb, in connecting the clock with downstream physiology of the pineal gland. Remarkably, knockdown of camk1gb disrupts locomotor activity in the whole larva, even though it is predominantly expressed within the pineal gland. Therefore, it appears that camk1gb plays a role in linking the pineal master clock with the periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.