ArticleProceedings of the National Academy of Sciences of the United States of America2013
Stable transgenesis in the marine annelid Platynereis dumerilii sheds new light on photoreceptor evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 100 citations in OpenAlex.
- Cells for blastema formation: Lessons from the annelid regenerative model.Cell and tissue research · 2026Review
- Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity.Nature communications · 2025Article
- Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.Nature communications · 2024Article
- Transgenesis enables mapping of segmental ganglia in the leech Helobdella austinensis.The Journal of experimental biology · 2024Article
- Dynamic microvilli sculpt bristles at nanometric scale.Nature communications · 2024Article
- Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment.Nature communications · 2022Article
- Two light sensors decode moonlight versus sunlight to adjust a plastic circadian/circalunidian clock to moon phase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rethinking Opsins.Molecular biology and evolution · 2022Article
- Ultrastructure of cerebral eyes in Oweniidae and Chaetopteridae (Annelida) - implications for the evolution of eyes in Annelida.Zoological letters · 2022Article
- Transgenesis in the acoel worm Hofstenia miamia.Developmental cell · 2021Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Article
- Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Integration of ocular and non-ocular photosensory information in the brain of the terrestrial slug Limax.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity.Science advances · 2020Article
- Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- CRISPR/CAS9 mutagenesis of a single r-opsin gene blocks phototaxis in a marine larva.Proceedings. Biological sciences · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Research in eye evolution has mostly focused on eyes residing in the head. In contrast, noncephalic light sensors are far less understood and rather regarded as evolutionary innovations. We established stable transgenesis in the annelid Platynereis, a reference species for evolutionary and developmental comparisons. EGFP controlled by cis-regulatory elements of r-opsin, a characteristic marker for rhabdomeric photoreceptors, faithfully recapitulates known r-opsin expression in the adult eyes, and marks a pair of pigment-associated frontolateral eyelets in the brain. Unexpectedly, transgenic animals revealed an additional series of photoreceptors in the ventral nerve cord as well as photoreceptors that are located in each pair of the segmental dorsal appendages (notopodia) and project into the ventral nerve cord. Consistent with a photosensory function of these noncephalic cells, decapitated animals display a clear photoavoidance response. Molecular analysis of the receptors suggests that they differentiate independent of pax6, a gene involved in early eye development of many metazoans, and that the ventral cells may share origins with the Hesse organs in the amphioxus neural tube. Finally, expression analysis of opn4×-2 and opn4m-2, two zebrafish orthologs of Platynereis r-opsin, reveals that these genes share expression in the neuromasts, known mechanoreceptors of the lateral line peripheral nervous system. Together, this establishes that noncephalic photoreceptors are more widespread than assumed, and may even reflect more ancient aspects of sensory systems. Our study marks significant advance for the understanding of photoreceptor cell (PRC) evolution and development and for Platynereis as a functional lophotrochozoan model system.
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