Trial reportJournal of the American Dental Association (1939)2013
Results from the Xylitol for Adult Caries Trial (X-ACT).
Trial report in Journal of the American Dental Association (1939), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Xylitol-containing products for preventing dental caries in children and adults.The Cochrane database of systematic reviews · 2015Pooled it
- The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults.Clinical oral investigations · 2017Trial
- Visual scoring of non cavitated caries lesions and clinical trial efficiency, testing xylitol in caries-active adults.Community dentistry and oral epidemiology · 2014Trial
- Tooth-surface-specific effects of xylitol: randomized trial results.Journal of dental research · 2013Trial
- The effect of allulose, sucralose, and xylitol onJADA foundational science · 2025Article
- Is xylitol effective in the prevention of dental caries? A systematic review.Journal of clinical and experimental dentistry · 2024Review
- Effectiveness of New Isomalt-Containing Toothpaste Formulations in Preventing Dental Caries: A Microbial Study.Dentistry journal · 2024Article
- A bivariate zero-inflated negative binomial model and its applications to biomedical settings.Statistical methods in medical research · 2023Article
- Effectiveness of the Lorodent Probiotic Lozenge in Reducing Plaque andFrontiers in oral health · 2022Article
- Using big data to promote precision oral health in the context of a learning healthcare system.Journal of public health dentistry · 2020Review
- METHODS FOR CARIES PREVENTION IN ADULTS AMONG DENTISTS FROM A BRAZILIAN COMMUNITY: Adult' caries prevention among Brazilian dentists.Brazilian journal of oral sciences · 2020Article
- A BAYESIAN HIERARCHICAL SPATIAL MODEL FOR DENTAL CARIES ASSESSMENT USING NON-GAUSSIAN MARKOV RANDOM FIELDS.The annals of applied statistics · 2016Article
- Comparing the efficacy of xylitol-containing and conventional chewing gums in reducing salivary counts of Streptococcus mutans: An in vivo study.Journal of International Society of Preventive & Community Dentistry · 2015Article
- The dynamic behavior of the early dental caries lesion in caries-active adults and implications.Community dentistry and oral epidemiology · 2015Article
- Caries: review of human genetics research.Caries research · 2014Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough caries is prevalent in adults, investigators have tested few preventive therapies in adult populations. In a randomized controlled trial, the authors evaluated the effectiveness of xylitol lozenges in preventing caries in adults at elevated risk of developing caries.
methodsThe Xylitol for Adult Caries Trial (X-ACT) was a three-site placebo-controlled randomized trial. Participants (n = 691) aged 21 through 80 years consumed five 1.0-gram xylitol or placebo lozenges daily for 33 months. They underwent clinical examinations at baseline and at 12, 24 and 33 months.
resultsXylitol lozenges reduced the caries increment 10 percent. This reduction, which represented less than one-third of a surface per year, was not statistically significant. There was no indication of a dose-response effect.
conclusionsDaily use of xylitol lozenges did not result in a statistically or clinically significant reduction in 33-month caries increment among adults at an elevated risk of developing caries. CLINICAL IMPLICATIONS: These results suggest that xylitol used as a supplement in adults does not reduce their caries experience significantly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.