ReviewStem cells translational medicine2013
Concise review: in search of unlimited sources of functional human pancreatic beta cells.
Review in Stem cells translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Association between remnant cholesterol and incident diabetic retinopathy in patients with type 2 diabetes: a prospective cohort study.Annals of medicine · 2026Article
- A Cell Metamodel Uncovers Mechanistic Drivers of Disease Phenotypes Across Molecular, Cellular, and Tissue Scales.Research square · 2025Article
- Glucose controls co-translation of structurally related mRNAsFrontiers in endocrinology · 2022Article
- The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their ZnOpen biology · 2020Article
- Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health.Diabetes · 2020Article
- The supply chain of human pancreatic β cell lines.The Journal of clinical investigation · 2019Review
- Reconstructing human pancreatic differentiation by mapping specific cell populations during development.eLife · 2017Article
- Dynamics of Insulin Secretion from EndoC-Journal of diabetes research · 2017Article
- Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.Scientific reports · 2016Article
- Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels.The Journal of physiology · 2015Article
- A human beta cell line with drug inducible excision of immortalizing transgenes.Molecular metabolism · 2015Article
- Genes affecting β-cell function in type 1 diabetes.Current diabetes reports · 2015Review
- Co-Culture of α TC-6 Cells and β TC-1 Cells: Morphology and Function.Endocrinology and metabolism (Seoul, Korea) · 2015Article
- Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.PloS one · 2015Article
- In search of a surrogate: engineering human beta cell lines for therapy.Trends in endocrinology and metabolism: TEM · 2014Article
- Development of a conditionally immortalized human pancreatic β cell line.The Journal of clinical investigation · 2014Article
- A synergistic therapeutic scheme for hyperglycemia and nephrotic disorders in diabetes.Theranostics · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well-established that insulin-producing pancreatic beta cells are central in diabetes. In type 1 diabetes, beta cells are destroyed by an autoimmune mechanism, whereas in type 2 diabetes, there is a decrease in functional beta-cell mass. In this context, studying beta cells is of major importance. Beta cells represent only 1% of total pancreatic cells and are found dispersed in the pancreatic gland. During the past decades, many tools and approaches have been developed to study rodent beta cells that efficiently pushed the field forward. However, rodent and human beta cells are not identical, and our knowledge of human beta cells has not progressed as quickly as our understanding of rodent beta cells. We believe that one of the reasons for this inefficient progress is the difficulty of accessing unlimited sources of functional human pancreatic beta cells. The main focus of this review concerns recent strategies to generate new sources of human pancreatic beta cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.