ArticleVirchows Archiv : an international journal of pathology2013
In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Prognostic and Clinical Value of Tumor-Associated Macrophages in Patients With Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- CD155 Expression in Invasive Breast Carcinoma: Association with Immune Tumor Microenvironment.Iranian journal of pathology · 2026Article
- Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma.Frontiers in cell and developmental biology · 2025Article
- Immunohistochemical Expression of CD47 and CD68 in Breast Carcinoma and Their Prognostic Value.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.Histology and histopathology · 2024Article
- Tumor associated macrophages in breast cancer progression: implications and clinical relevance.Frontiers in immunology · 2024Review
- Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer.Frontiers in immunology · 2024Review
- Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes.Cancer science · 2023Review
- Spatial and Quantitative Analysis of Tumor-Associated Macrophages: Intratumoral CD163-/PD-L1+ TAMs as a Marker of Favorable Clinical Outcomes in Triple-Negative Breast Cancer.International journal of molecular sciences · 2022Article
- Enhancing Fatty Acid Catabolism of Macrophages Within Aberrant Breast Cancer Tumor Microenvironment Can Re-establish Antitumor Function.Frontiers in cell and developmental biology · 2021Article
- Immune microenvironment in different molecular subtypes of ductal breast carcinoma.Breast cancer research and treatment · 2021Review
- The Distinct Impact of TAM Infiltration on the Prognosis of Patients With Cardia and Non-Cardia Gastric Cancer and Its Association WithFrontiers in oncology · 2021Article
- CD68- and CD163-positive tumor-associated macrophages in triple negative cancer of the breast.Virchows Archiv : an international journal of pathology · 2020Article
- Development and verification of a personalized immune prognostic feature in breast cancer.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Pathologic assessment of tumor-associated macrophages and their histologic localization in invasive breast carcinoma.Journal of the Egyptian National Cancer Institute · 2020Article
- Tumor-Associated Neutrophils and Macrophages-Heterogenous but Not Chaotic.Frontiers in immunology · 2020Review
- Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.Frontiers in immunology · 2020Review
- Age-related remodelling of the blood immunological portrait and the local tumor immune response in patients with luminal breast cancer.Clinical & translational immunology · 2020Article
- Diverse Functions of Macrophages in Different Tumor Microenvironments.Cancer research · 2018Review
- Stromal Infiltration of Tumor-Associated Macrophages Conferring Poor Prognosis of Patients with Basal-Like Breast Carcinoma.Journal of Cancer · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
Tumor-associated macrophages play a crucial role in breast cancer progression and tumor angiogenesis. However, evaluation of tumor-associated macrophages incorporating their histological locations is lacking. The aim of this study was to clarify whether macrophages in tumor stroma and macrophages in tumor cell nests have distinctive properties in relation to pertinent breast cancer clinicopathological parameters and tumor angiogenesis. In 94 human invasive breast ductal carcinomas, tumor-associated macrophages were immunostained with anti-CD68 antibody and counted or graded according to these histological locations. Microvessels were immunostained with anti-CD34 antibody and counted for microvessel density. We found that the presence of tumor stromal and tumor nest macrophages was closely correlated (p = 0.001). Both tumor stromal and tumor nest macrophages were associated with mitotic count (p = 0.001 and p = 0.037, respectively). However, only higher tumor stromal macrophage grades were associated with higher tumor grades (p = 0.004) and negative estrogen receptor status (p = 0.007). Multivariate analysis showed that tumors with a high mitotic count score (score 3 vs. scores 1 and 2) had a higher tumor stromal macrophage density (Grades III and IV) when adjusted for tumor size, tubule formation, and estrogen receptor status (odds ratio 3.41, p = 0.010). The tumor nest macrophage count significantly correlated with the microvessel density (p < 0.001). These results imply that tumor stromal macrophages and tumor nest macrophages residing in different tumor microenvironments have distinctive roles.
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