ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 67 citations in OpenAlex.
- Investigating the interactions between multiple memory stores in the pond snail Lymnaea stagnalis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- FOXO inBiology · 2023Article
- Identification of Putative Molecules for Adiponectin and Adiponectin Receptor and Their Roles in Learning and Memory inBiology · 2023Article
- Changes in protein phosphorylation by insulin administration in the central nervous system of the gastropod molluskBiophysics and physicobiology · 2023Article
- Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Insulin and Memory in Invertebrates.Frontiers in behavioral neuroscience · 2022Review
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- The pond snail Lymnaea stagnalis.EvoDevo · 2020Review
- Review
- Effect of photoperiod and light intensity on learning ability and memory formation of the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Monoamines, Insulin and the Roles They Play in Associative Learning in Pond Snails.Frontiers in behavioral neuroscience · 2019Review
- Comparison of brain monoamine content in three populations ofBiophysics and physicobiology · 2018Article
- Green tea and cocoa enhance cognition inCommunicative & integrative biology · 2018Article
- Two Strains ofFrontiers in behavioral neuroscience · 2017Article
- Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea.Biology open · 2016Article
- Function of insulin in snail brain in associative learning.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Molluscs as models for translational medicine.Medical science monitor basic research · 2015Article
- Effects of serotonin on the heartbeat of pond snails in a hunger state.Biophysics (Nagoya-shi, Japan) · 2015Article
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Authors and funding
18 authors at 7 institutions in 2 countries.
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Abstract
The pond snail Lymnaea stagnalis is capable of learning taste aversion and consolidating this learning into long-term memory (LTM) that is called conditioned taste aversion (CTA). Previous studies showed that some molluscan insulin-related peptides (MIPs) were upregulated in snails exhibiting CTA. We thus hypothesized that MIPs play an important role in neurons underlying the CTA-LTM consolidation process. To examine this hypothesis, we first observed the distribution of MIP II, a major peptide of MIPs, and MIP receptor and determined the amounts of their mRNAs in the CNS. MIP II was only observed in the light green cells in the cerebral ganglia, but the MIP receptor was distributed throughout the entire CNS, including the buccal ganglia. Next, when we applied exogenous mammalian insulin, secretions from MIP-containing cells or partially purified MIPs, to the isolated CNS, we observed a long-term change in synaptic efficacy (i.e., enhancement) of the synaptic connection between the cerebral giant cell (a key interneuron for CTA) and the B1 motor neuron (a buccal motor neuron). This synaptic enhancement was blocked by application of an insulin receptor antibody to the isolated CNS. Finally, injection of the insulin receptor antibody into the snail before CTA training, while not blocking the acquisition of taste aversion learning, blocked the memory consolidation process; thus, LTM was not observed. These data suggest that MIPs trigger changes in synaptic connectivity that may be correlated with the consolidation of taste aversion learning into CTA-LTM in the Lymnaea CNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.