ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
DRD4 genotype predicts longevity in mouse and human.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.bioRxiv : the preprint server for biology · 2025Article
- Fmo induction as a tool to screen for pro-longevity drugs.GeroScience · 2024Article
- Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment.Addiction neuroscience · 2023Article
- Effects of family income on brain functional connectivity in US children: associations with cognition.Molecular psychiatry · 2023Article
- Serotonin and dopamine modulate aging in response to food odor and availability.Nature communications · 2022Article
- Klerman's "credo" reconsidered: neo-Kraepelinianism, Spitzer's views, and what we can learn from the past.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- G protein-coupled receptors that influence lifespan of human and animal models.Biogerontology · 2022Review
- Association between PolymorphismGenes · 2021Article
- Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.Aging cell · 2021Article
- Environmental influences on the pace of brain development.Nature reviews. Neuroscience · 2021Review
- Article
- Methylation-related metabolic effects of D4 dopamine receptor expression and activation.Translational psychiatry · 2019Article
- Evolution of sex-specific pace-of-life syndromes: genetic architecture and physiological mechanisms.Behavioral ecology and sociobiology · 2018Review
- Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.Oncotarget · 2016Article
- Article
- Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle.PloS one · 2016Article
- Article
- A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly.Personality and individual differences · 2015Article
- DRD4 Genotype and the Developmental Link of Peer Social Preference with Conduct Problems and Prosocial Behavior Across Ages 9-12 Years.Journal of youth and adolescence · 2015Article
- Increased brain activity to unpleasant stimuli in individuals with the 7R allele of the DRD4 gene.Psychiatry research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 3 countries.
Funding
Abstract
Longevity is influenced by genetic and environmental factors. The brain's dopamine system may be particularly relevant, since it modulates traits (e.g., sensitivity to reward, incentive motivation, sustained effort) that impact behavioral responses to the environment. In particular, the dopamine D4 receptor (DRD4) has been shown to moderate the impact of environments on behavior and health. We tested the hypothesis that the DRD4 gene influences longevity and that its impact is mediated through environmental effects. Surviving participants of a 30-year-old population-based health survey (N = 310; age range, 90-109 years; the 90+ Study) were genotyped/resequenced at the DRD4 gene and compared with a European ancestry-matched younger population (N = 2902; age range, 7-45 years). We found that the oldest-old population had a 66% increase in individuals carrying the DRD4 7R allele relative to the younger sample (p = 3.5 × 10(-9)), and that this genotype was strongly correlated with increased levels of physical activity. Consistent with these results, DRD4 knock-out mice, when compared with wild-type and heterozygous mice, displayed a 7-9.7% decrease in lifespan, reduced spontaneous locomotor activity, and no lifespan increase when reared in an enriched environment. These results support the hypothesis that DRD4 gene variants contribute to longevity in humans and in mice, and suggest that this effect is mediated by shaping behavioral responses to the environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.