ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Functional differentiation of a population of electrically coupled heterogeneous elements in a microcircuit.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
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- Self-Attention-Based Contextual Modulation Improves Neural System Identification.... International Conference on Learning Representations · 2025Article
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- Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.Scientific reports · 2023Article
- Characterization of anFrontiers in pharmacology · 2023Article
- Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis inFrontiers in neural circuits · 2023Article
- Identification of an allatostatin C signaling system in mollusc Aplysia.Scientific reports · 2022Article
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- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Gap Junction Coding Innexin inFrontiers in synaptic neuroscience · 2020Article
- cGMP mediates short- and long-term modulation of excitability in a decision-making neuron in Aplysia.Neuroscience letters · 2018Article
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Use of theJournal of neurophysiology · 2017Review
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.Journal of neurophysiology · 2015Article
- Electrical coupling and innexin expression in the stomatogastric ganglion of the crab Cancer borealis.Journal of neurophysiology · 2014Article
Corrections and comments
- Erratum issuedSasaki, Kosai [corrected to Sasaki, Kosei]
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Although electrical coupling is present in many microcircuits, the extent to which it will determine neuronal firing patterns and network activity remains poorly understood. This is particularly true when the coupling is present in a population of heterogeneous, or intrinsically distinct, circuit elements. We examine this question in the Aplysia californica feeding motor network in five electrically coupled identified cells, B64, B4/5, B70, B51, and a newly identified interneuron B71. These neurons exhibit distinct activity patterns during the radula retraction phase of motor programs. In a subset of motor programs, retraction can be flexibly extended by adding a phase of network activity (hyper-retraction). This is manifested most prominently as an additional burst in the radula closure motoneuron B8. Two neurons that excite B8 (B51 and B71) and one that inhibits it (B70) are active during hyper-retraction. Consistent with their near synchronous firing, B51 and B71 showed one of the strongest coupling ratios in this group of neurons. Nonetheless, by manipulating their activity, we found that B51 preferentially acted as a driver of B64/B71 activity, whereas B71 played a larger role in driving B8 activity. In contrast, B70 was weakly coupled to other neurons and its inhibition of B8 counteracted the excitatory drive to B8. Finally, the distinct firing patterns of the electrically coupled neurons were fine-tuned by their intrinsic properties and the largely chemical cross-inhibition between some of them. Thus, the small microcircuit of the Aplysia feeding network is advantageous in understanding how a population of electrically coupled heterogeneous neurons may fulfill specific network functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.