Evidence map›Paper›PMID 23283176›Full record

ArticleThe World Allergy Organization journal2011

Interleukin-13 signaling and its role in asthma.

Efren L Rael, Richard F Lockey

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 199 citations in OpenAlex.

  1. Review
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  11. Therapeutic effects of a combination ofFrontiers in nutrition · 2025
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  16. A study of inflammatory biomarkers in crystalline silica exposed rock drillers.International archives of occupational and environmental health · 2024
    Article
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  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Efren L RaelFrom the 1Department of Allergy, Asthma and Immunology, Penn State Hershey Medical Center MCH0401, Hershey, PA; 2University Distinguished Health Professor, Professor of Medicine, Pediatrics & Public Health; Director, Division of Allergy & Immunology, Joy McCann Culverhouse Chair in Allergy & Immunology; World Allergy Organization President; University of South Florida College of Medicine University of South Florida; James A. Haley Veterans' Hospital, Department of A/I (111D), Tampa, FL.
Richard F Lockey
Penn State Milton S. Hershey Medical Center · USWorld Allergy Organization · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma affects nearly 300 million people worldwide. The majority respond to inhaled corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to 10% with severe asthma do not respond optimally to these medications. Different phenotypes of asthma may explain why current therapies show limited benefits in subgroups of patients. Interleukin-13 is implicated as a central regulator in IgE synthesis, mucus hypersecretion, airway hyperresponsiveness, and fibrosis. Promising research suggests that the interleukin-13 pathway may be an important target in the treatment of the different asthma phenotypes.

Identifiers

PMID23283176
PMCPMC3651056
OpenAlexW2114703024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.