Evidence map›Paper›PMID 23283106›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2012

Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience.

Uri Lindner, Sangeet Ghai, Paula Spensieri, Eugen Hlasny, Theodorus H Van Der Kwast, Stuart A McCluskey, Masoom A Haider, Walter Kucharczyk, John Trachtenberg

Registry-linked trialAbstract read
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01226576 (Focal MR-Guided Focused Ultrasound Treatment of Localized Low-Intermediate Risk Prostate Cancer), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01226576 nacompletednot on this map

Focal MR-Guided Focused Ultrasound Treatment of Localized Low-Intermediate Risk Prostate Cancer: Feasibility Study

TypeinterventionalSponsorInSightecRan2010 to 2018Enrolled8ConditionsLocalized Low-Intermediate Risk Prostate CancerArmsMRgFUS Treatment
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  2. Review of Robot-Assisted HIFU Therapy.Sensors (Basel, Switzerland) · 2023
    Review
  3. Review
  4. Article
  5. Magnetic resonance image-guided focused ultrasound robotic system for transrectal prostate cancer therapy.The international journal of medical robotics + computer assisted surgery : MRCAS · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Update on Clinical Magnetic Resonance-Guided Focused Ultrasound Applications.Magnetic resonance imaging clinics of North America · 2015
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Focal therapy for prostate cancer: rationale and treatment opportunities.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2013
    Review
  15. Article
  16. MRI-guided biopsies and minimally invasive therapy for prostate cancer.Indian journal of urology : IJU : journal of the Urological Society of India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Uri LindnerDivision of Urology, Department of Surgical Oncology, University Health Network, and Department of Surgery, University of Toronto, Toronto, ON;
Sangeet Ghai
Paula Spensieri
Eugen Hlasny
Theodorus H Van Der Kwast
Stuart A McCluskey
Masoom A Haider
Walter Kucharczyk
John Trachtenberg
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of low-risk prostate cancer is a common clinical dilemma between standard curative whole gland therapy (and its associated quality of life diminishing side effects) and active surveillance (and its low, but real, risk of progression). The goal of focal therapy in low-risk prostate cancer is to achieve the best balance between cancer control and maintenance of quality of life. Magnetic resonance-guided focused ultrasound (MRgFUS) surgery is a non-invasive thermal ablation method that integrates magnetic resonance imaging for target identification, treatment planning and closed-loop control of thermal deposition and focused ultrasound for thermal ablation of the tumour target. This novel transrectal system allows for tumour localization, targeting and monitoring of tumour target ablation in real time, while simultaneously preserving adjacent normal tissue thereby minimizing the side effects of standard curative surgical or radiation therapy. We report the first North American clinical experience of treatment of localized prostate cancer with focal MR-guided transrectal focused ultrasound (clinicaltrial.gov identifier NCT01226576).

Identifiers

PMID23283106
PMCPMC3529739
OpenAlexW2110647243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.