ReviewThe American journal of surgical pathology2013
KSHV/HHV8-negative effusion-based lymphoma, a distinct entity associated with fluid overload states.
Review in The American journal of surgical pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Fluid overload-associated large B-cell lymphoma: two case report and review of literature.Frontiers in oncology · 2025Pooled it
- Clinicopathologic and molecular features of primary effusion lymphoma and fluid overload-associated large B-cell lymphoma: A retrospective study.Translational oncology · 2026Article
- Multi-cavity Primary Effusion Lymphoma in a Cirrhotic Patient: A Rare Cause of Chylous Effusion.Cureus · 2026Article
- Isolated Pleural Effusion as Presentation of a Large B-Cell Lymphoma: A Case Report and Diagnostic Considerations.Journal of clinical laboratory analysis · 2026Article
- Fluid Overload-Associated Large B-Cell Lymphoma Presenting as Isolated Pleural Effusion.Hematology reports · 2026Article
- Large B-cell lymphoma associated with fluid overload: two new case reports with molecular insights.Virchows Archiv : an international journal of pathology · 2026Article
- Diagnostic challenge of aneurysmal dermatofibroma mimicking cutaneous metastasis in a patient with lung cancer: A case report.Experimental and therapeutic medicine · 2026Article
- A Rare Case of Fluid Overload-Associated Large B-Cell Lymphoma in a Patient With Hepatitis C Cirrhosis.ACG case reports journal · 2026Article
- Intrathoracic manifestations of hematologic malignancies: a narrative review.Annals of translational medicine · 2025Review
- Article
- Proteasome inhibitors prevent tumor cell proliferation in HHV-8-unrelated PEL-like lymphoma.Leukemia research reports · 2025Article
- Discrepancy of Hans' criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with MYD88 L265P mutation.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Monomorphic T-cell post-transplant lymphoproliferative disorder with features of HHV8-negative primary effusion lymphoma: an autopsy case and review of the literature.Medical molecular morphology · 2024Review
- What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?Journal of hematopathology · 2024Review
- Promising immunotherapeutic approaches for primary effusion lymphoma.Exploration of targeted anti-tumor therapy · 2024Review
- Primary Effusion Lymphoma-like Lymphoma Mimicking Tuberculous Pleural Effusion: Three Case Reports and a Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.Virchows Archiv : an international journal of pathology · 2023Article
- Fluid Overload-Associated Large B-Cell Lymphoma: A Case Report and Review of Literature.Hematology reports · 2023Article
- [Classification of aggressive B-cell lymphomas : News and open questions].Pathologie (Heidelberg, Germany) · 2023Review
- HHV8 and EBV-negative primary effusion-based lymphoma: A case report of a new provisional entity and review of literature.Clinical case reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human herpesvirus-8 (HHV8)-positive effusion-based lymphomas have been termed primary effusion lymphoma (PEL) in the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Kaposi sarcoma herpesvirus (KSHV)/HHV8-negative effusion-based lymphomas (KSHV/HHV8-negative EBLs) resembling PELs have been reported in the literature and in many cases have been (mis)classified as PEL-like lymphomas. Herein, we present a series of cases and a review of KSHV/HHV8-negative EBLs. This lymphoma, although cytomorphologically resembling PEL, is a distinct entity with characteristic clinical and pathologic features. Patients are older, generally human immunodeficiency virus negative and not immunosuppressed, frequently hepatitis C positive compared with the population baseline, and often have an underlying medical condition leading to fluid overload. The lymphoma cells express pan-B-cell antigens in 86.7%, and CD20 is expressed in 71.1% of the cases. The lymphoma is often of germinal center B or mixed germinal center B/activated B-cell signature with the Hans classifier, and Epstein-Barr virus is positive in nearly 30% of cases. Rare T-cell lymphomas were also reported. Clinical outcomes and response to therapy, including isolated aspiration, are relatively favorable compared with cases of PEL. We suggest that HHV8-negative effusion-based lymphoma is a distinct entity associated with fluid overload states.
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