ArticleMalaria journal2013
Studying fitness cost of Plasmodium falciparum infection in malaria vectors: validation of an appropriate negative control.
Article in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness.Malaria journal · 2021Trial
- Additional blood meals increase sporozoite infection in Anopheles mosquitoes but not Plasmodium falciparum genetic diversity.Scientific reports · 2024Article
- Mosquito ageing modulates the development, virulence and transmission potential of pathogens.Proceedings. Biological sciences · 2024Article
- Evaluation of insemination, blood feeding, and Plasmodium vivax infection effects on locomotor activity patterns of the malaria vector Anopheles darlingi (Diptera: Culicidae).Parasitology research · 2023Article
- Malaria rapid diagnostic tests reliably detect asymptomatic Plasmodium falciparum infections in school-aged children that are infectious to mosquitoes.Parasites & vectors · 2023Article
- Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.PLoS pathogens · 2023Article
- Analyzing gut microbiota composition in individualiScience · 2021Article
- Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.Parasites & vectors · 2021Article
- Detection of Plasmodium falciparum in laboratory-reared and naturally infected wild mosquitoes using near-infrared spectroscopy.Scientific reports · 2021Article
- Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field.Malaria journal · 2021Article
- Effect of irradiation on the survival and susceptibility of female Anopheles arabiensis to natural isolates of Plasmodium falciparum.Parasites & vectors · 2020Article
- Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda.Malaria journal · 2019Article
- Efficacy of vector control tools against malaria-infected mosquitoes.Scientific reports · 2019Article
- Malaria infection in mosquitoes decreases the personal protection offered by permethrin-treated bednets.Parasites & vectors · 2018Article
- Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control.Cold Spring Harbor perspectives in medicine · 2017Review
- No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum.Scientific reports · 2017Article
- Larval nutritional stress affects vector life history traits and human malaria transmission.Scientific reports · 2016Article
- Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria.PLoS pathogens · 2016Article
- Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe question whether Plasmodium falciparum infection affects the fitness of mosquito vectors remains open. A hurdle for resolving this question is the lack of appropriate control, non-infected mosquitoes that can be compared to the infected ones. It was shown recently that heating P. falciparum gametocyte-infected blood before feeding by malaria vectors inhibits the infection. Therefore, the same source of gametocyte-infected blood could be divided in two parts, one heated, serving as the control, the other unheated, allowing the comparison of infected and uninfected mosquitoes which fed on exactly the same blood otherwise. However, before using this method for characterizing the cost of infection to mosquitoes, it is necessary to establish whether feeding on previously heated blood affects the survival and fecundity of mosquito females.
methodsAnopheles gambiae M molecular form females were exposed to heated versus non-heated, parasite-free human blood to mimic blood meal on non-infectious versus infectious gametocyte-containing blood. Life history traits of mosquito females fed on blood that was heat-treated or not were then compared.
resultsThe results reveal that heat treatment of the blood did not affect the survival and fecundity of mosquito females. Consistently, blood heat treatment did not affect the quantity of blood ingested.
conclusionsThe study indicates that heat inactivation of gametocyte-infected blood will only inhibit mosquito infection and that this method is suitable for quantifying the fitness cost incurred by mosquitoes upon infection by P. falciparum.
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