Trial reportJournal of clinical hypertension (Greenwich, Conn.)2013
Effect of valsartan with bedtime dosing on chronic kidney disease patients with nondipping blood pressure pattern.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nighttime Valsartan on Prognosis of Nocturnal Hypertension Patients Undergoing Maintenance Hemodialysis
Effect of Potassium Losartan With Bedtime Dosing on Chronic Kidney Disease Patients With Nondipping Blood Pressure Pattern
Prognostic Effect of Isolated Nocturnal Hypertension Pattern With Nondialysis CKD
Effect of Nighttime Losartan on Prognosis of Nocturnal Hypertension Patients Undergoing Continous Ambulatory Peritoneal Dialysis
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease.The Cochrane database of systematic reviews · 2023Pooled it
- Chronotherapy for hypertension in patients with chronic kidney disease: a systematic review and meta-analysis in non-black patients.International urology and nephrology · 2017Pooled it
- Understanding Efficacy of Using ACEIs and ARBs in Chronotherapeutic Treatment of Hypertension: Which Drug When?Current hypertension reviews · 2025Review
- Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm.Frontiers in cardiovascular medicine · 2021Review
- Nocturnal blood pressure is associated with sympathetic nerve activity in patients with chronic kidney disease.Physiological reports · 2020Article
- Chronotherapy with a Renin-angiotensin System Inhibitor Ameliorates Renal Damage by Suppressing Intrarenal Renin-angiotensin System Activation.Internal medicine (Tokyo, Japan) · 2020Article
- Circadian rhythms and the kidney.Nature reviews. Nephrology · 2018Review
- Chronotherapy for Hypertension.Current hypertension reports · 2018Review
- Night-time blood pressure and pulse wave velocity in dialysis patients.Clinical and experimental nephrology · 2018Article
- Hypertension in patients with CKD in China: clinical characteristics and management.Frontiers of medicine · 2017Article
- Prognostic Effect of Isolated Nocturnal Hypertension in Chinese Patients With Nondialysis Chronic Kidney Disease.Journal of the American Heart Association · 2016Article
- Prognostic Value of Reverse Dipper Blood Pressure Pattern in Chronic Kidney Disease Patients not Undergoing Dialysis: Prospective Cohort Study.Scientific reports · 2016Article
- Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time?Kidney international reports · 2016Article
- Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Review
- Nocturnal Hypertension Correlates Better With Target Organ Damage in Patients With Chronic Kidney Disease than a Nondipping Pattern.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- High prevalence of isolated nocturnal hypertension in Chinese patients with chronic kidney disease.Journal of the American Heart Association · 2015Article
- Chronotherapeutics of conventional blood pressure-lowering medications: simple, low-cost means of improving management and treatment outcomes of hypertensive-related disorders.Current hypertension reports · 2014Review
- Article
- Effect of Chronotherapy of Antihypertensives in Chronic Kidney Disease: A Randomized Control Trial.Indian journal of nephrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nondipping blood pressure (BP) pattern is a potential independent risk factor for chronic kidney disease (CKD). Bedtime administration of valsartan is considered to normalize circadian rhythm and protect the kidneys and heart in CKD patients. However, more clinical trials are needed to confirm this benefit. Sixty patients with nondipping BP pattern and thirty patients with dipping BP pattern were enrolled in this study, and the patients with nondipping BP pattern were randomly divided into two groups and treated with bedtime or awakening doses of valsartan (80-320 mg). Nondipping BP patients treated with bedtime doses of valsartan showed a greater reduction in 24-hour proteinuria and bedtime proteinuria, a greater delayed decline in estimated glomerular filtration rate, and more protection against myocardial hypertrophy (P<.05) compared with patients with the nondipping BP pattern treated with the awakening dose (P<.05). This was similar to patients with dipping BP. No severe clinical complications were recorded in these patients. Valsartan with bedtime dosing in CKD patients with the nondipping BP pattern have better renal and cardiovascular protection. Antihypertensive "chronotherapy" may be useful in clinical practice for CKD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.