ArticleJournal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)2013
Exploring dissociation and oxytocin as pathways between trauma exposure and trauma-related hyperemesis gravidarum: a test-of-concept pilot.
Article in Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Prenatal maternal posttraumatic stress disorder as a risk factor for adverse birth weight and gestational age outcomes: A systematic review and meta-analysis.Journal of affective disorders · 2021Pooled it
- Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.Psychological review · 2023Article
- Oxytocin receptor gene, post-traumatic stress disorder and dissociation in a community sample of European American women.BJPsych open · 2022Article
- An Investgation About the Relationship Between Vasopressin and Oxytocin in Persistent Type Functional Neurological Symptom Disorder.Psychiatry investigation · 2021Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- The oxytocinergic system in PTSD following traumatic childbirth: endogenous and exogenous oxytocin in the peripartum period.Archives of women's mental health · 2020Review
- Cognitive and neural facets of dissociation in a traumatized population.Emotion (Washington, D.C.) · 2019Article
- A Pilot Study of Oxytocin in Low-Income Women With a Low Birth-Weight Infant: Is Oxytocin Related to Posttraumatic Stress?Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2019Article
- Exploring the mutual regulation between oxytocin and cortisol as a marker of resilience.Archives of psychiatric nursing · 2019Article
- Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Autism, oxytocin and interoception.Neuroscience and biobehavioral reviews · 2014Review
- Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders.Frontiers in neuroscience · 2013Article
- Posttraumatic oxytocin dysregulation: is it a link among posttraumatic self disorders, posttraumatic stress disorder, and pelvic visceral dysregulation conditions in women?Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD) · 2010Review
- The prevalence of posttraumatic stress disorder during pregnancy and postpartum period.Journal of family medicine and primary careArticle
- In search of an adult attachment stress provocation to measure effect on the oxytocin system: a pilot validation study.Journal of the American Psychiatric Nurses AssociationArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is associated with gastrointestinal and genitourinary comorbidities. These map onto the somatization disorder symptoms in the Diagnostic and Statistical Manual of Mental Disorders ( American Psychiatric Association, 1994 ) and the dissociative (conversion) disorders symptoms in the International Classification of Diseases taxonomy ( World Health Organization, 2007 ). Hyperemesis gravidarum (HG) is one of these symptoms and a gastrointestinal comorbidity of PTSD occurring in pregnancy. It is an idiopathic condition defined as severe vomiting with dehydration, metabolic imbalance, wasting, and hospital care seeking. HG is more severe than the normative phenomenon of nausea and vomiting of pregnancy. This test-of-concept pilot (N = 25) explored the hypothesis that there is a trauma-related subtype of HG characterized by (a) high levels of dissociative symptoms and (b) altered plasma concentrations of oxytocin. This hypothesis is informed by a theory of posttraumatic oxytocin dysregulation that posits altered oxytocin function as a mechanism of gut smooth muscle peristalsis dysfunction. A 4-group analysis compared controls with nausea and vomiting of pregnancy (NV only) and cases with HG only, NV and PTSD, or HG and PTSD. Oxytocin was correlated with the nausea and vomiting symptom severity score (r = .464, p = .019) and with the dissociation symptom score (r = .570, p = .003). Women in the group with both PTSD and HG (the trauma-related HG subtype) had the highest levels of dissociation and the highest levels of oxytocin. A linear regression model indicated that the independent association of the trauma-related HG subtype with oxytocin level was mediated by high levels of dissociative symptoms.
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Registered trials
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