ArticleBMC systems biology2012
MicroRNA 3' end nucleotide modification patterns and arm selection preference in liver tissues.
Article in BMC systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
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- Regulation of hepatic microRNAs in response to early stage Echinococcus multilocularis egg infection in C57BL/6 mice.PLoS neglected tropical diseases · 2020Article
- Comprehensive identification of microRNA arm selection preference in lung cancer: miR-324-5p and -3p serve oncogenic functions in lung cancer.Oncology letters · 2018Article
- The discovery potential of RNA processing profiles.Nucleic acids research · 2018Article
- MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee.Scientific reports · 2017Article
- Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.Scientific reports · 2016Article
- Alcohol Use During Pregnancy is Associated with Specific Alterations in MicroRNA Levels in Maternal Serum.Alcoholism, clinical and experimental research · 2016Article
- Attomole quantification and global profile of RNA modifications: Epitranscriptome of human neural stem cells.Nucleic acids research · 2016Article
- Uridylation and adenylation of RNAs.Science China. Life sciences · 2015Review
- Deep sequencing shows microRNA involvement in bovine mammary gland adaptation to diets supplemented with linseed oil or safflower oil.BMC genomics · 2015Article
- New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer.BMC genomics · 2015Article
- Chimira: analysis of small RNA sequencing data and microRNA modifications.Bioinformatics (Oxford, England) · 2015Article
- Evaluation and application of the strand-specific protocol for next-generation sequencing.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe expression of microRNA (miRNA) genes undergoes several maturation steps. Recent studies brought new insights into the maturation process, but also raised debates on the maturation mechanism. To understand the mechanism better, we downloaded small RNA sequence reads from NCBI SRA and quantified the expression profiles of miRNAs in normal and tumor liver tissues.
resultsFrom these miRNA expression profiles, we studied several issues related to miRNA biogenesis. First of all, the 3' ends of mature miRNAs usually carried modified nucleotides, generated from nucleotide addition or RNA editing. We found that adenine accounted for more than 50% of all miRNA 3' end modification events in all libraries. However, uracil dominated over adenine in several miRNA types. Moreover, the miRNA reads in the HBV-associated libraries have much lower rates of nucleotide modification. These results indicate that miRNA 3' end modifications are miRNA specific and may differ between normal and tumor tissues. Secondly, according to the hydrogen-bonding theory, the expression ratio of 5p arm to 3p arm miRNAs, derived from the same pre-miRNA, should be constant over tissues. However, a comparison of the expression profiles of the 5p arm and 3p arm miRNAs showed that one arm is preferred in the normal liver tissue whereas the other is preferred in the tumor liver tissue. In other words, different liver tissues have their own preferences on selecting either arm to be mature miRNAs.
conclusionsThe results suggest that besides the traditional miRNA biogenesis theory, another mechanism may also participate in the miRNA biogenesis pathways.
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