ArticleCancer science2013
Inverse association between cancer risks and age in schizophrenic patients: a 12-year nationwide cohort study.
Article in Cancer science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies.Journal of public health (Oxford, England) · 2026Pooled it
- Lung cancer incidence in patients with schizophrenia: meta-analysis.The British journal of psychiatry : the journal of mental science · 2019Pooled it
- Association of Schizophrenia With the Risk of Breast Cancer Incidence: A Meta-analysis.JAMA psychiatry · 2018Pooled it
- Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses.PLoS genetics · 2014Pooled it
- Association between Antipsychotic Drug and Survival in Patients with Lung Cancer Treated with Chemoradiotherapy: A Nationwide Korean Cohort Study.Cancer research and treatment · 2025Article
- Breast cancer risk among women with schizophrenia and association with duration of antipsychotic use: population-based cohort study in South Korea.The British journal of psychiatry : the journal of mental science · 2025Article
- Understanding the role of dopamine in cancer: past, present and future.Carcinogenesis · 2022Review
- Trifluoperazine and Its Analog Suppressed the Tumorigenicity of Non-Small Cell Lung Cancer Cell; Applicability of Antipsychotic Drugs to Lung Cancer Treatment.Biomedicines · 2022Article
- Molecular crosstalk between cancer and neurodegenerative diseases.Cellular and molecular life sciences : CMLS · 2020Review
- The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study.Epidemiology and psychiatric sciences · 2020Article
- Identification of shared genetic variants between schizophrenia and lung cancer.Scientific reports · 2018Article
- Lower risk of liver cancer in patients with schizophrenia: a systematic review and meta-analysis of cohort studies.Oncotarget · 2017Article
- Cancer-Incidence, prevalence and mortality in the oldest-old. A comprehensive review.Mechanisms of ageing and development · 2017Review
- Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine?Frontiers in oncology · 2015Review
- Inflammation and the two-hit hypothesis of schizophrenia.Neuroscience and biobehavioral reviews · 2014Review
- Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.Journal of schizophrenia researchArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between schizophrenia and cancer risk is contentious in the clinical and epidemiological literature. Studies from different populations, tumor sites, or health care systems have provided inconsistent findings. In the present study, we examined a less well-investigated hypothesis that age plays a crucial role in cancer risk in schizophrenia. We conducted a nationwide cohort study using Taiwan's National Health Insurance Research Database (NHIRD) between 1995 and 2007. Overall, gender-, and age-stratified standardized incidence ratios (SIR) were used to investigate the pattern of cancer risk by age. Of the 102 202 schizophrenic patients, 1738 developed cancer after a diagnosis of schizophrenia (SIR = 0.92; 95% confidence interval [CI] 0.90-0.96). However, the age-stratified SIR declined with age (e.g. SIR [95% CI] = 1.97 [1.85-2.33], 0.68 [0.65-0.78], and 0.36 [0.34-0.45] for those aged 20-29, 60-69, and ≥70 years, respectively) in both genders and for major cancers. Cancer risks in schizophrenic patients were lower for cancers that are more likely to develop at an older age in the general population (e.g. stomach cancer [SIR = 0.62; 95% CI 0.57-0.80], pancreatic cancer [SIR = 0.49; 95% CI 0.39-0.84], and prostate cancer [SIR = 0.35; 95% CI 0.29-0.58]). In contrast, cancer risks were higher for cancers that have a younger age of onset, such as cancers of the nasopharynx (SIR = 1.18; 95% CI 1.08-1.49), breast (SIR = 1.50; 95% CI 1.44-1.66) and uterine corpus (SIR = 2.15; 95% CI 1.98-2.74). The unique age structures and early aging potential of schizophrenia populations may contribute to the observed inverse relationship between age and cancer risk. Higher cancer comorbidity in young schizophrenic patients deserves more attention.
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