ReviewCurrent eye research2013
New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.
Review in Current eye research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Increased dendritic cell density and altered morphology in allergic conjunctivitis.Eye (London, England) · 2023Observational
- Dendritic Cell Density and Morphology Can Be Used to Differentiate Vernal Keratoconjunctivitis from Allergic Conjunctivitis.Biomolecules · 2023Article
- Dendritiform immune cells with reduced antigen-capture capacity persist in the cornea during the asymptomatic phase of allergic conjunctivitis.Eye (London, England) · 2023Article
- Ocular Surface Inflammatory Disorders (OSID): A Collective of Systemic Etiologies Which Cause or Amplify Dry Eye Syndrome.Frontiers in medicine · 2022Article
- The Role of Temperature Change, Ambient Temperature, and Relative Humidity in Allergic Conjunctivitis in a US Veteran Population.American journal of ophthalmology · 2021Article
- The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.The ocular surface · 2021Review
- Discovery to Launch of Anti-allergy (Emadine; Patanol/Pataday/Pazeo) and Anti-glaucoma (Travatan; Simbrinza) Ocular Drugs, and Generation of Novel Pharmacological Tools Such as AL-8810.ACS pharmacology & translational science · 2020Article
- Complement and CD4eLife · 2019Article
- Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions.Frontiers in pharmacology · 2019Article
- Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice.Scientific reports · 2017Article
- Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Surveillance Tools Emerging From Search Engines and Social Media Data for Determining Eye Disease Patterns.JAMA ophthalmology · 2016Article
- Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines.Eye & contact lens · 2016Review
- Ocular itch associated with allergic conjunctivitis: latest evidence and clinical management.Therapeutic advances in chronic disease · 2016Review
- Linking immune responses with fibrosis in allergic eye disease.Current opinion in allergy and clinical immunology · 2015Review
- Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease.Investigative ophthalmology & visual science · 2015Article
- T helper subsets in allergic eye disease.Current opinion in allergy and clinical immunology · 2014Review
- The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation.The ocular surface · 2014Review
- Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
Abstract
The prevalence of allergy is rising globally at a very significant rate, which is currently at 20-40% of individuals in westernized nations. In the eye, allergic conditions can take on the acute form such as in seasonal and perennial allergic conjunctivitis, or a more severe and debilitating chronic form such as in vernal and atopic keratoconjunctivitis. Indeed, some key aspects of allergic eye disease pathophysiology are understood, such as the role of mast cells in the acute allergic reaction, and the contribution of eosinophils in late-onset and chronic allergy. However, recent developments in animal models and clinical studies have uncovered new and important roles for previously underappreciated players, including chemokine receptors on ocular surface dendritic cells such as CCR7, the contribution of conjunctival epithelium to immunity, histamine and leukotriene receptors on conjunctival goblet cells and a role for mast cells in late-onset manifestations. Furthermore, recent work in animal models has delineated the contribution of IL-4 in the increased incidence of corneal graft rejection in hosts with allergic conjunctivitis. Recent studies such as these mean that conventional paradigms and concepts should be revisited. The aim of this review is to highlight some of the most recent advances and insights on newly appreciated players in the pathogenesis of allergic eye disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.