ArticleClinical pharmacology and therapeutics2013
Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU.
Article in Clinical pharmacology and therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04953169 (Examining Health Literacy in Biorepository Consents), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining Health Literacy in Biorepository Consents
Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- AI-based multimodal integration of genomics and electronic health records.Nature reviews. Genetics · 2026Review
- Biobanking with genetics shapes precision medicine and global health.Nature reviews. Genetics · 2025Review
- Pediatric CYP2D6 metabolizer status and post-tonsillectomy nausea and vomiting after ondansetron.Clinical and translational science · 2023Article
- Novel diabetes gene discovery through comprehensive characterization and integrative analysis of longitudinal gene expression changes.Human molecular genetics · 2022Article
- Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate.Human molecular genetics · 2022Article
- Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population.Clinical and translational science · 2022Article
- Population-based genetic effects for developmental stuttering.HGG advances · 2022Article
- Adolescent perceptions of pharmacogenetic testing.Pharmacogenomics · 2021Article
- Adolescent Assent and Reconsent for Biobanking: Recent Developments and Emerging Ethical Issues.Frontiers in medicine · 2021Review
- Article
- Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020Article
- Article
- Adverse Events Associated with Risperidone Use in Pediatric Patients: A Retrospective Biobank Study.Drugs - real world outcomes · 2019Article
- Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.Journal of the American College of Cardiology · 2019Article
- CYP2D6 genotype and adverse events to risperidone in children and adolescents.Pediatric research · 2019Article
- Article
- Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins.Seminars in perinatology · 2018Review
- Beyond Consent: Building Trusting Relationships With Diverse Populations in Precision Medicine Research.The American journal of bioethics : AJOB · 2018Article
- Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors.Drug safety · 2018Article
- Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities.Journal of personalized medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The Vanderbilt DNA repository, BioVU, links DNA from leftover clinical blood samples to de-identified electronic medical records (EMRs). After initiating adult sample collection, pediatric extension required consideration of ethical concerns specific to pediatrics and implementation of specialized DNA extraction methods. In the first year of pediatric sample collection, more than 11,000 samples from individuals younger than 18 years were included. We compared data from the pediatric BioVU cohort with those from the overall Vanderbilt University Medical Center pediatric population and found similar demographic characteristics; however, the BioVU cohort had higher rates of select diseases, medication exposures, and laboratory testing, demonstrating enriched representation of severe or chronic disease. The fact that the sample accumulation is not balanced may accelerate research in some cohorts while limiting the study of relatively benign conditions and the accrual of unaffected and unbiased control samples. BioVU represents a feasible model for pediatric DNA biobanking but involves both ethical and practical considerations specific to the pediatric population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.