Evidence map›Paper›PMID 23281412›Full record

ReviewThe Journal of clinical investigation2013

New approaches under development: cardiovascular embryology applied to heart disease.

Karl Degenhardt, Manvendra K Singh, Jonathan A Epstein

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Hippo Signaling Pathway in Cardiac Development and Diseases.Frontiers in cell and developmental biology · 2019
    Review
  2. In Vitro Culture of Epicardial Cells From Mouse Embryonic Heart.Journal of visualized experiments : JoVE · 2016
    Article
  3. Review
  4. Review
  5. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2014
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karl DegenhardtDivision of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Manvendra K Singh
Jonathan A Epstein

Funding

Expansion of cardiac and hematopoietic progenitors by Wnt and NotchU01HL100405 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, JONATHAN A., MORRISEY, EDWARD E · 2009 to 2015
$8.1M
The Role of Sema3D in Cardiac DevelopmentK08HL094763 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI DEGENHARDT, KARL · 2011 to 2014
$520k
NHLBI NIH HHS K08 HL094763NHLBI NIH HHS K08HL094763-02NHLBI NIH HHS U01 HL100405
6 · The paper itself

Abstract

Despite many innovative advances in cardiology over the past 50 years, heart disease remains a major killer. The steady progress that continues to be made in diagnostics and therapeutics is offset by the cardiovascular consequences of the growing epidemics of obesity and diabetes. Truly innovative approaches on the horizon have been greatly influenced by new insights in cardiovascular development. In particular, research in stem cell biology, the cardiomyocyte lineage, and the interactions of the myocardium and epicardium have opened the door to new approaches for healing the injured heart.

Indexed as

AnimalsDiabetes ComplicationsHeart DiseasesHumansMyocardiumObesityPericardium

Identifiers

PMID23281412
PMCPMC3533277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.