ArticleThe Journal of clinical investigation2013
Deimination restores inner retinal visual function in murine demyelinating disease.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- The Role of Deimination in Regenerative Reprogramming of Neurons.Molecular neurobiology · 2019Article
- Integrative properties of retinal ganglion cell electrical responsiveness depend on neurotrophic support and genotype in the mouse.Experimental eye research · 2016Article
- Transgenic mice expressing mutated Tyr437His human myocilin develop progressive loss of retinal ganglion cell electrical responsiveness and axonopathy with normal iop.Investigative ophthalmology & visual science · 2014Article
- Robust mouse pattern electroretinograms derived simultaneously from each eye using a common snout electrode.Investigative ophthalmology & visual science · 2014Article
- Retinal deimination and PAD2 levels in retinas from donors with age-related macular degeneration (AMD).Experimental eye research · 2013Article
- A new mouse model of inducible, chronic retinal ganglion cell dysfunction not associated with cell death.Investigative ophthalmology & visual science · 2013Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of damage to the axons and soma of neurons. Here, we show that dendritic impairment is also involved in these diseases. Deimination, a posttranslational modification, was reduced in the retinal ganglion cell layer of MS patients and in a transgenic mouse model of MS (ND4 mice). Reduced deimination accompanied a decrease in inner retinal function in ND4 mice, indicating loss of vision. Local restoration of deimination dramatically improved retinal function and elongation of neurites in isolated neurons. Further, neurite length was decreased by downregulation of deimination or siRNA knockdown of the export-binding protein REF, a primary target for deimination in these cells. REF localized to dendrites and bound selective mRNAs and translation machinery to promote protein synthesis. Thus, protein deimination and dendritic outgrowth play key roles in visual function and may be a general feature of demyelinating diseases.
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Registered trials
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