ArticleCytoskeleton (Hoboken, N.J.)2013
Conserved structural motifs in the central pair complex of eukaryotic flagella.
Article in Cytoskeleton (Hoboken, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 97 citations in OpenAlex.
- Article
- Tubulin glutamylation: a key regulator of flagella, cilia, centrosomes, and disease pathways.Journal of biomedical science · 2026Review
- JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution.EMBO reports · 2026Article
- In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia.Cell research · 2025Article
- Ccdc13 is essential for the assembly of ciliary central microtubules.National science review · 2025Article
- Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.Asian journal of andrology · 2025Article
- CEP104/FAP256 and associated cap complex maintain stability of the ciliary tip.The Journal of cell biology · 2023Article
- Concurrent loss of ciliary genesRoyal Society open science · 2023Article
- In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.Nature structural & molecular biology · 2023Article
- Molecular architecture of the ciliary tip revealed by cryo-electron tomography.bioRxiv : the preprint server for biology · 2023Article
- Calaxin is required for asymmetric bend initiation and propagation in sperm flagella.Frontiers in cell and developmental biology · 2023Article
- Three-dimensional flagella structures from animals' closest unicellular relatives, the Choanoflagellates.eLife · 2022Article
- Flagellar energy costs across the tree of life.eLife · 2022Article
- A look under the hood of the machine that makes cilia beat.Nature structural & molecular biology · 2022Article
- Ciliary central apparatus structure reveals mechanisms of microtubule patterning.Nature structural & molecular biology · 2022Article
- Cryo-EM structure of an active central apparatus.Nature structural & molecular biology · 2022Article
- Electron cryo-tomography structure of axonemal doublet microtubule fromLife science alliance · 2022Article
- Electron microscopy for imaging organelles in plants and algae.Plant physiology · 2022Article
- Structural organization of the C1b projection within the ciliary central apparatus.Journal of cell science · 2021Article
- Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.Nature communications · 2021Article
3 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Cilia and flagella are conserved hair-like appendages of eukaryotic cells that function as sensing and motility generating organelles. Motility is driven by thousands of axonemal dyneins that require precise regulation. One essential motility regulator is the central pair complex (CPC) and many CPC defects cause paralysis of cilia/flagella. Several human diseases, such as immotile cilia syndrome, show CPC abnormalities, but little is known about the detailed three-dimensional (3D) structure and function of the CPC. The CPC is located in the center of typical [9+2] cilia/flagella and is composed of two singlet microtubules (MTs), each with a set of associated projections that extend toward the surrounding nine doublet MTs. Using cryo-electron tomography coupled with subtomogram averaging, we visualized and compared the 3D structures of the CPC in both the green alga Chlamydomonas and the sea urchin Strongylocentrotus at the highest resolution published to date. Despite the evolutionary distance between these species, their CPCs exhibit remarkable structural conservation. We identified several new projections, including those that form the elusive sheath, and show that the bridge has a more complex architecture than previously thought. Organism-specific differences include the presence of MT inner proteins in Chlamydomonas, but not Strongylocentrotus, and different overall outlines of the highly connected projection network, which forms a round-shaped cylinder in algae, but is more oval in sea urchin. These differences could be adaptations to the mechanical requirements of the rotating CPC in Chlamydomonas, compared to the Strongylocentrotus CPC which has a fixed orientation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.