ArticleBirth defects research. Part A, Clinical and molecular teratology2013
Association between reported venlafaxine use in early pregnancy and birth defects, national birth defects prevention study, 1997-2007.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Medication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies.Orphanet journal of rare diseases · 2024Pooled it
- Maternal exposure to SSRIs or SNRIs and the risk of congenital abnormalities in offspring: A systematic review and meta-analysis.PloS one · 2023Pooled it
- A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants.Drug safety · 2021Pooled it
- Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- Consensus Panel Recommendations for the Pharmacological Management of Pregnant Women with Depressive Disorders.International journal of environmental research and public health · 2023Article
- Fetal Surgery for Gastroschisis-A Review with Emphasis on Minimally Invasive Procedures.Children (Basel, Switzerland) · 2022Review
- Venlafaxine prescription claims among insured women of reproductive age and pregnant women, 2011-2016.Birth defects research · 2021Article
- Brain-Derived Neurotrophic Factor (BDNF) Depression and Subjective Sleep Quality in the First Trimester of Pregnancy Among Migrant Workers in Thailand.Journal of multidisciplinary healthcare · 2021Article
- Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects.JAMA psychiatry · 2020Article
- Review
- A machine learning approach to investigate potential risk factors for gastroschisis in California.Birth defects research · 2019Article
- Medicolegal Review: Perinatal Effexor Lawsuits and Legal Strategies Adverse to Prescribing Obstetric Providers.AJP reports · 2019Review
- Gastroschisis and Cumulative Stressor Exposures.Epidemiology (Cambridge, Mass.) · 2018Article
- Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study.BMJ (Clinical research ed.) · 2017Article
- Article
- Databases for Congenital Heart Defect Public Health Studies Across the Lifespan.Journal of the American Heart Association · 2016Review
- The Risk of Congenital Heart Anomalies Following Prenatal Exposure to Serotonin Reuptake Inhibitors-Is Pharmacogenetics the Key?International journal of molecular sciences · 2016Review
- Depression and Anxiety During Pregnancy: Evaluating the Literature in Support of Clinical Risk-Benefit Decision-Making.Current psychiatry reports · 2016Review
- Cardiac dysfunction and prenatal exposure to venlafaxine.Clinical case reports · 2016Article
- Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS).Birth defects research. Part A, Clinical and molecular teratology · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundFew epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine during pregnancy is associated with specific birth defects.
methodsWe used data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study in the United States. Our analysis included mothers with pregnancies affected by one of 30 selected birth defects (cases) and babies without birth defects (controls) with estimated dates of delivery between 1997 and 2007. Exposure was any reported use of venlafaxine from 1 month preconception through the third month of pregnancy. We calculated adjusted odds ratios (aORs) and 95% Fisher Exact confidence intervals (CIs) for 24 birth defect groups for which at least 400 case mothers were interviewed. Our adjusted analyses controlled for maternal age and race/ethnicity.
resultsAmong the 27,045 NBDPS participants who met inclusion criteria, 0.17% (14/8002) of control mothers and 0.40% (77/19,043) of case mothers reported any use of venlafaxine from 1 month preconception through the third month of pregnancy. Statistically significant associations were found for anencephaly, atrial septal defect (ASD) secundum, or ASD not otherwise specified, coarctation of the aorta, cleft palate, and gastroschisis.
conclusionsOur data suggest associations between periconceptional use of venlafaxine and some birth defects. However, sample sizes were small, CIs were wide, and additional studies are needed to confirm these results.
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