Evidence map›Paper›PMID 23281051›Full record

ReviewBioFactors (Oxford, England)

Retinoids: Potent regulators of metabolism.

Pierre-Jacques Brun, Kryscilla Jian Zhang Yang, Seung-Ah Lee, Jason J Yuen, William S Blaner

Open access · greenAbstract readReview
In one paragraph

Review in BioFactors (Oxford, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Vitamin A and Its Related Diseases.Food science & nutrition · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Retinoic Acid Signaling in Fatty Liver Disease.Liver research (Beijing, China) · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Heliyon · 2022
    Article
  15. The consumption of micronutrients in relation to calorie intake and risk of insulin resistance.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pierre-Jacques BrunDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Kryscilla Jian Zhang Yang
Seung-Ah Lee
Jason J Yuen
William S Blaner
Columbia University · US

Funding

POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Postprandial Vitamin AR01DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2004 to 2023
$7.0M
Retinoid Metabolism and Alcohol Induced DiseaseRC2AA019413 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2009 to 2010
$1.8M
Vitamin A Storage and MetabolismR01DK079221 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2007 to 2010
$1.3M
Alcohol Consumption and Brown Adipose TissueR21AA021336 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2013 to 2014
$414k
NHLBI NIH HHS T32 HL007343NIAAA NIH HHS R21 AA021336NIAAA NIH HHS RC2 AA019413NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK079221
6 · The paper itself

Abstract

Retinoids (vitamin A and its analogs) are highly potent regulators of cell differentiation, cell proliferation, and apoptosis. Because of these activities, retinoids have been most extensively studied in the contexts of embryonic development and of proliferative diseases, especially cancer and skin disease. Recently, there has been considerable new research interest focused on gaining understanding of the roles that retinoids and/or retinoid-related proteins may have in the development of metabolic diseases, primarily obesity, diabetes, and dyslipidemia. This review will summarize recent advances that have been made in these areas, focusing on the role of retinoids in modulating adipogenesis, the roles of retinoids and retinoid-related proteins as signaling molecules linking obesity with the development of type II diabetes, the roles of retinoids in pancreatic β-cell biology/insulin secretion, and the actions of retinoids in hepatic steatosis.

Indexed as

Adipose TissueAnimalsGlucoseHumansMetabolic DiseasesRetinoidsVitamin AGlucoseRetinoidsVitamin A

Identifiers

PMID23281051
PMCPMC3620893
OpenAlexW2040684708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.