Evidence map›Paper›PMID 23280775›Full record

ArticleEuropean journal of pain (London, England)2013

Reciprocal longitudinal associations between pain and depressive symptoms in adolescents.

A Lewandowski Holley, E F Law, C Zhou, L Murphy, G Clarke, T M Palermo

Abstract read
In one paragraph

Article in European journal of pain (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Sleep deficiency and symptoms of pain, fatigue, and depressed mood in youth with and without childhood systemic lupus erythematosus.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
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  13. Co-occurring depression and pain in multiple sclerosis.Physical medicine and rehabilitation clinics of North America · 2013
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A Lewandowski HolleyDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, USA. Amy.lewandowski@seattlechildrens.org
E F Law
C Zhou
L Murphy
G Clarke
T M Palermo

Funding

Sleep-wake disturbances in adolescents with chronic painR01HD053431 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI PALERMO, TONYA M · 2007 to 2011
$1.7M
Innovations in Pediatric Pain ResearchK24HD060068 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI PALERMO, TONYA M · 2009 to 2018
$1.6M
Chronic Pain in Pediatric Primary CareK23HD071946 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI LEWANDOWSKI HOLLEY, AMY S · 2012 to 2016
$583k
NICHD NIH HHS K23 HD071946NICHD NIH HHS K23HD071946NICHD NIH HHS K24 HD060068NICHD NIH HHS R01HD05343NICHD NIH HHS R01 HD053431
6 · The paper itself

Abstract

backgroundElevated depressive symptoms are common in youth with chronic pain, and pain symptoms are frequent in adolescents with depressive disorders. While studies have identified concurrent associations between pain and depression over time in youth, it is unclear how change in one symptom impacts change in the other symptom.

methodsThis three-time point 12-month longitudinal study examined reciprocal associations among pain and depression in a clinical sample of adolescents (12-18) diagnosed with chronic pain (n = 55) or a depressive disorder (n = 40). Mixed-effects multivariate models were used to test if changes over a preceding time interval predicted symptom severity at subsequent time points. Study group, age, sex, race, baseline pain intensity and baseline depressive symptoms were included as covariates.

resultsGeneralized estimating equations revealed that pain and depressive symptoms were significantly associated over time (β = 1.54; p < 0.001). As hypothesized, changes in pain were associated with subsequent depressive symptoms (β = 1.16; p < 0.001). Conversely, changes in depressive symptoms predicted subsequent pain (β = 0.026; p < 0.05), but with a weaker association. In the model predicting pain, an interaction between depressive symptoms and study group emerged (β = -0.02; p < 0.05), with change in depressive symptoms having the greatest impact on pain in the depressed sample.

conclusionsFindings extend previous adult research to an adolescent sample showing changes in pain intensity are predictive of subsequent depressive symptoms. In comparison to adult data, changes in depressive symptoms had less impact on subsequent pain in youth. Future research can examine how targeting persistent pain may also aid the treatment of depressive symptoms in adolescents.

Indexed as

AdolescentAge FactorsChildDepressionFemaleHumansLongitudinal StudiesMalePainPain MeasurementRisk Factors

Identifiers

PMID23280775
PMCPMC3620896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.