Trial reportHuman psychopharmacology2013
Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine.
Trial report in Human psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Biobehavioral and affective stress responses during nicotine withdrawal: Influence of regular cannabis co-use.Psychopharmacology · 2024Article
- Article
- Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress.Psychopharmacology · 2022Article
- Chronic stress, autonomic dysregulation and prospective drug use among African American emerging adults.Cultural diversity & ethnic minority psychology · 2022Article
- Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping.Frontiers in psychology · 2021Review
- Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future.Neuroscience and biobehavioral reviews · 2019Review
- [Effect of clinical characteristics on relapse of alcohol dependence: a prospective cohort study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Drug-induced stress responses and addiction risk and relapse.Neurobiology of stress · 2019Review
- Heavy marijuana use but not deprivation is associated with increased stressor reactivity.Journal of abnormal psychology · 2018Article
- Marijuana Use and Hypothalamic-Pituitary-Adrenal Axis Functioning in Humans.Frontiers in psychiatry · 2018Review
- Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis.Addictive behaviors · 2017Observational
- Demographic and clinical characteristics of treatment seeking women with full and subthreshold PTSD and concurrent cannabis and cocaine use disorders.Journal of substance abuse treatment · 2017Article
- Acute Pulmonary Injury after Inhalation of Free-Base Cocaine: A Case Report.Journal of acute medicine · 2017Article
- Substance use modulates stress reactivity: Behavioral and physiological outcomes.Physiology & behavior · 2016Review
- Altered subjective reward valuation among drug-deprived heavy marijuana users: Aversion to uncertainty.Journal of abnormal psychology · 2016Article
- Needed Relapse-Prevention Research on Novel Framework (ASPIRE Model) for Substance Use Disorders Treatment.Frontiers in psychiatry · 2015Review
- Cocaine influences alcohol-seeking behavior and relapse drinking in alcohol-preferring (P) rats.Alcoholism, clinical and experimental research · 2014Article
- Stress modulates illness-course of substance use disorders: a translational review.Frontiers in psychiatry · 2014Review
- Elevated Norepinephrine may be a Unifying Etiological Factor in the Abuse of a Broad Range of Substances: Alcohol, Nicotine, Marijuana, Heroin, Cocaine, and Caffeine.Substance abuse : research and treatment · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo date, little research exists defining bio-behavioral adaptations associated with both marijuana abuse and risk of craving and relapse to other drugs of abuse during early abstinence.
methodFifty-nine treatment-seeking individuals dependent on alcohol and cocaine were recruited. Thirty of these individuals were also marijuana (MJ) dependent; 29 were not. Twenty-six socially drinking healthy controls were also recruited. All participants were exposed to three 5-min guided imagery conditions (stress, alcohol/cocaine cue and relaxing), presented randomly, one per day across three consecutive days. Measures of craving, anxiety, heart rate, blood pressure, plasma adrenocorticotrophic hormone and cortisol were collected at baseline and subsequent recovery time points.
resultsThe MJ-dependent group showed increased basal anxiety ratings and cardiovascular output alongside enhanced alcohol craving and cocaine craving, and dampened cardiovascular response to stress and cue. They also demonstrated elevated cue-induced anxiety and stress-induced cortisol and adrenocorticotrophic hormone levels, which were not observed in the non-MJ-dependent group or controls. Cue-related alcohol craving and anxiety were both predictive of a shorter number of days to marijuana relapse following discharge from inpatient treatment.
conclusionsFindings provide some support for drug cross-sensitization in terms of motivational processes associated with stress-related and cue-related craving and relapse.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.