ReviewInternational journal of cancer2013
Is acute myeloid leukemia a liquid tumor?
Review in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Bilateral proptosis as the first manifestation in a patient with acute myeloid leukemia: Case report.Medicine · 2026Article
- eIF4E and Ezrin cooperate in pseudopods to drive a localized migratory translation program in acute myeloid leukemia.bioRxiv : the preprint server for biology · 2026Article
- Evacuation of axillary hematoma causing brachial plexus compression in newly diagnosed leukemia: a case report and literature review.Case reports in plastic surgery & hand surgery · 2026Article
- A fatal case of peritonitis due to colonic localization of acute myeloid leukemia.Annals of hematology · 2025Article
- Tumor-Infiltration Mimicking Model of Contaminated Ovarian Tissue as an Innovative Platform for Advanced Cancer Research.The AAPS journal · 2024Article
- Myeloid sarcoma: more and less than a distinct entity.Annals of hematology · 2023Review
- Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Extramedullary Myeloid Leukemia in the Setting of a Myeloproliferative Neoplasm.Journal of medical cases · 2022Article
- Gastric Myeloid Sarcoma Mimicking a Scirrhous Gastric Cancer.Internal medicine (Tokyo, Japan) · 2022Article
- Clinical characteristics, pathology features and outcomes of pediatric myeloid sarcoma: A retrospective case series.Frontiers in pediatrics · 2022Article
- Clinical Characteristics and Treatment Outcomes of Myeloid Sarcoma in Children: The Experience of the Polish Pediatric Leukemia and Lymphoma Study Group.Frontiers in oncology · 2022Article
- Non-invasive image-based cytometry for high throughput NK cell cytolysis analysis.Journal of immunological methods · 2021Article
- Extramedullary Involvement in Acute Myeloid Leukemia. A Single Center Ten Years' Experience.Mediterranean journal of hematology and infectious diseases · 2021Article
- Differential Localization and Invasion of Tumor Cells in Mouse Models of Human and Murine Leukemias.Acta histochemica et cytochemica · 2020Article
- Characteristics of myeloid sarcoma in mice and patients withOncology letters · 2020Article
- Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia.Biomarker research · 2020Article
- RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis.International journal of molecular sciences · 2019Review
- Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies.Frontiers in oncology · 2019Article
- Circular RNA regulatory network reveals cell-cell crosstalk in acute myeloid leukemia extramedullary infiltration.Journal of translational medicine · 2018Article
- Uterine Mass and Menorrhagia: A Rare Presentation of Acute Myeloid Leukemia with Arduous Clinical CourseBalkan medical journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Extramedullary manifestations of acute myeloid leukemia (AML) were described as early as the 19th century. However, the incidence, clinical significance and pathobiology of extramedullary AML remain ill defined. We reviewed case reports, retrospective case series, pilot studies and imaging studies of extramedullary leukemia (EML) to determine its frequency, characteristics, clinical presentation and significance. EML precedes or accompanies development of AML and occurs during or following treatment, even during remission. Although imaging studies are rarely conducted and the true incidence of EML has yet to be verified, authors have reported several estimates based on retrospective and autopsy studies. The incidence of EML in patients with AML of all ages is estimated to be about 9% and EML in children with AML was detected in 40% of patients at diagnosis. The combination of positron emission tomography and computed tomography were the most sensitive and reliable techniques of detecting and monitoring EML. Based on our literature review, the frequency of EML is likely underreported. The well-documented nature of EML in patients with AML suggests that AML can manifest as a solid tumor. The extent to which EML accompanies AML and whether EML is derived from bone marrow are unknown. Furthermore, questions remain regarding the role of the microenvironment, which may or may not facilitate the survival and proliferation of EML, and the implications of these interactions with regard to minimal residual disease, tumor cell quiescence and relapse. Therefore, prospective studies of detection and characterization of EML in patients with AML are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.