ArticleArthritis and rheumatism2013
The fibromyalgia family study: a genome-wide linkage scan study.
Article in Arthritis and rheumatism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 9 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 9 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies.Current pain and headache reports · 2024Pooled it
- Mirtazapine for fibromyalgia in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Aerobic exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2017Pooled it
- Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Gabapentin for fibromyalgia pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Cannabinoids for fibromyalgia.The Cochrane database of systematic reviews · 2016Pooled it
- Antipsychotics for fibromyalgia in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Selective serotonin reuptake inhibitors for fibromyalgia syndrome.The Cochrane database of systematic reviews · 2015Pooled it
- Aquatic exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2014Pooled it
- Prenatal Stress, Enteric Nervous System Development, and the Microbiota-Gut-Brain Axis: A Hypothesis-Generating Framework for Irritable Bowel Syndrome and Fibromyalgia.International journal of molecular sciences · 2026Review
- The genetic architecture of fibromyalgia across 2.5 million individuals.Nature medicine · 2026Article
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- The associations between age, familial occurrence of fibromyalgia, and symptom severity in fibromyalgia: a cross-sectional study from a Finnish health center.BMC rheumatology · 2026Article
- Evaluating skin biopsy findings in fibromyalgia: a systematic review.Reumatologia · 2026Review
- The genetic architecture of fibromyalgia across 2.5 million individuals.medRxiv : the preprint server for health sciences · 2025Article
- Fibromyalgia: are you a genetic/environmental disease?Pain reports · 2025Review
- Juvenile Primary Fibromyalgia Syndrome: Advances in Etiopathogenesis, Clinical Assessment and Treatment: A Narrative Review.Biomedicines · 2025Review
- Small Fibre Pathology in Fibromyalgia: A review.Pain and therapy · 2025Review
- Fibromyalgia: Understanding, Diagnosis and Modern Approaches to Treatment.Journal of clinical medicine · 2025Review
- The genetics of pain.BJA education · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveFamilial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.
methodsWe genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.
resultsThe estimated sibling recurrence risk ratio (λs ) for fibromyalgia was 13.6 (95% confidence interval 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe ]=0.00030) and D17S1294 (Pe=0.00035) on chromosome 17p11.2-q11.2.
conclusionThe estimated sibling recurrence risk ratio (λs ) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.