ArticleJAMA2013
Outcomes using lower vs higher hemoglobin thresholds for red blood cell transfusion.
Article in JAMA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02648113 (Cost-effectiveness and Cost-utility of Liberal vs Restrictive Red Blood Cell Transfusion Strategies in Patients With Acute Myocardial Infarction and Anaemia. The REALITY), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cost-effectiveness and Cost-utility of Liberal vs Restrictive Red Blood Cell Transfusion Strategies in Patients With Acute Myocardial Infarction and Anaemia. The REALITY (REstrictive And LIberal Transfusion Strategies in Patients With Acute mYocardial Infarction) Randomized Trial.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Restrictive vs. Liberal Red Blood Cell Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews.BMC medicine · 2020Pooled it
- Transfusion of red blood cells stored for shorter versus longer duration for all conditions.The Cochrane database of systematic reviews · 2018Pooled it
- Meta-analytic estimation of measurement variability and assessment of its impact on decision-making: the case of perioperative haemoglobin concentration monitoring.BMC medical research methodology · 2016Pooled it
- Trial
- Assessment of hematologic parameters before and after bimaxillary orthognathic surgery.Oral and maxillofacial surgery · 2016Trial
- Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial.Trials · 2015Trial
- Clinical outcomes of anemia in patients with spontaneous coronary artery dissection: a retrospective cohort analysis.Journal of thrombosis and thrombolysis · 2026Article
- Lower Hemoglobin Following Adult Spine Deformity Surgery Leads to Longer Hospital Length of Stay.Cureus · 2025Article
- Review
- Article
- Clinical outcomes and prediction nomogram model for postoperative hemoglobin < 80 g/L in patients following primary lumbar interbody fusion surgery.Journal of orthopaedic surgery and research · 2023Article
- Effect of epidural analgesia on long-term outcomes after curative surgery for pancreatic cancer: A single-center cohort study in Taiwan.Journal of the Chinese Medical Association : JCMA · 2022Article
- Restrictive vs liberal red blood cell transfusion strategies in patients with acute myocardial infarction and anemia: Rationale and design of the REALITY trial.Clinical cardiology · 2021Article
- Impact of COVID-19 on blood centres in Zhejiang province China.Vox sanguinis · 2020Article
- Application of Perioperative Transfusion Trigger Score in Patients Undergoing Surgical Treatment of Malignant Tumor.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- Article
- RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support.Critical care medicine · 2018Observational
- Gender differences in the association between discharge hemoglobin and 12-month mortality after acute myocardial infarction.Clinical cardiology · 2017Article
- Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure.Intensive care medicine experimental · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
clinical questionIs a lower vs higher hemoglobin threshold best for minimizing both red blood cell use and adverse clinical outcomes when used to trigger red blood cell transfusions in anemic patients in critical care and acute care settings? BOTTOM LINE: Compared with higher hemoglobin thresholds, a hemoglobin threshold of 7 or 8 g/dL is associated with fewer red blood cell units transfused without adverse associations with mortality, cardiac morbidity, functional recovery, or length of hospital stay.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.