ArticleCancer2013
An aggregated analysis of hormonal factors and endometrial cancer risk by parity.
Article in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07435623 (Assessment of Late Gastrointestinal and Genitourinary Toxicities in Cervical and Endometrial Cancer Requiring Postoperative IMRT and/or Brachytherapy), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Late Gastrointestinal and Genitourinary Toxicities in Cervical and Endometrial Cancer Requiring Postoperative IMRT and/or Brachytherapy
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Insights and limitations of endometrial cancer risk prediction models for clinical applicability: a systematic review.BMC cancer · 2025Pooled it
- Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.International journal of cancer · 2015Trial
- Preoperative and postoperative pathology concordance in endometrial intraepithelial neoplasia: A retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Gene Expression Profiling of Peripheral Blood and Endometrial Cancer Risk Factors: Systems Epidemiology Approach in the NOWAC Postgenome Cohort Study.Lifestyle genomics · 2026Article
- Hybrid ResNet-ViT Framework for Endometrial Lesion Analysis: A Comparative Study of MRI and CT in Endometrial Cancer Classification.International journal of women's health · 2025Article
- Evaluation of endometrial thickness by transvaginal ultrasound and baseline risk factors as a predictor for endometrial abnormalities in postmenopausal women.Australasian journal of ultrasound in medicine · 2022Article
- Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: Results from the prospective IETA-1 cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Observational
- Case report: Spontaneous remission of synchronous endometrial and ovarian cancers following pregnancy.Frontiers in oncology · 2022Article
- Article
- Risk of Pre-Malignancy or Malignancy in Postmenopausal Endometrial Polyps: A CHAID Decision Tree Analysis.Diagnostics (Basel, Switzerland) · 2021Article
- Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort.Safety and health at work · 2020Article
- Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer.BioMed research international · 2020Article
- Enriching Personalized Endometrial Cancer Research with the Harmonization of Biobanking Standards.Cancers · 2019Review
- Association of Combined Estrogen-Progestogen and Progestogen-Only Contraceptives with the Development of Cancer.The Linacre quarterly · 2018Review
- Lifetime number of years of menstruation as a risk index for postmenopausal endometrial cancer in the Norwegian Women and Cancer Study.Acta obstetricia et gynecologica Scandinavica · 2018Article
- Harmonisation of biobanking standards in endometrial cancer research.British journal of cancer · 2017Article
- Reproductive factors and incidence of endometrial cancer in U.S. black women.Cancer causes & control : CCC · 2017Article
- Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women.American journal of epidemiology · 2016Article
- Intra-Individual Consistency in Endocrine Profiles Across Successive Pregnancies.The Journal of clinical endocrinology and metabolism · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNulliparity is associated with an increased risk of endometrial cancer. It is less clear whether nulliparity modifies the association between other established hormone-related risk factors. The proportion of nulliparous women has increased since the mid-1970s, but most individual studies to date have been too small to test the hypothesis that endometrial cancer risk factors may be associated more strongly with risk among nulliparous women compared with parous women.
methodsData were aggregated on 26,936 postmenopausal, Caucasian, nulliparous women (360 endometrial cancers) and 146,583 postmenopausal, Caucasian, parous women (1378 endometrial cancers) from 4 US prospective studies (1979-2006). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in stratified analyses.
resultsThe risk of endometrial cancer was higher among nulliparous women than among parous women, as expected (nulliparous vs parous: HR, 1.42; 95% CI, 1.26-1.60). Stratified associations between endometrial cancer and hormone-related risk factors did not differ between nulliparous versus parous women: For both groups, oral contraceptives and earlier menopause were associated with reduced risk. The highest HRs were for obesity: A body mass index ≥30 kg/m(2) (vs <25 kg/m(2) ) increased the risk of endometrial cancer 3-fold among nulliparous women (HR, 3.04; 95% CI, 2.34-3.94) and parous women (HR, 2.88; 95% CI, 2.52-3.29).
conclusionsThe results from this large, pooled analysis of data from 4 large prospective studies suggested that nulliparity does not modify the risks of endometrial cancer associated with established hormone-related risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.