ArticleVeterinary microbiology2013
Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV).
Article in Veterinary microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Characteristics of an emerging canine respiratory coronavirus in China.The veterinary quarterly · 2025Article
- Development and validation of nanoplate-based RT-dPCR assay for canine respiratory coronavirus detection in various clinical samples.BMC veterinary research · 2025Article
- Detection of pathogens in dogs with respiratory disease during winter 2023-2024 using multiplex qPCR/RT-qPCR assays and next-generation sequencing.Frontiers in veterinary science · 2025Article
- Canine respiratory coronavirus in Thailand undergoes mutation and evidences a potential putative parent for genetic recombination.Microbiology spectrum · 2023Article
- Coronavirus and the Cytoskeleton of Virus-Infected Cells.Sub-cellular biochemistry · 2023Article
- Review
- Clinical and molecular aspects of veterinary coronaviruses.Virus research · 2021Review
- Animal Coronaviruses and SARS-COV-2 in Animals, What Do We Actually Know?Life (Basel, Switzerland) · 2021Review
- Evolution, Interspecies Transmission, and Zoonotic Significance of Animal Coronaviruses.Frontiers in veterinary science · 2021Review
- Pathology of Coronavirus Infections: A Review of Lesions in Animals in the One-Health Perspective.Animals : an open access journal from MDPI · 2020Review
- Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model.Pathogens (Basel, Switzerland) · 2020Review
- Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features.Viruses · 2020Review
- Cytoskeleton-a crucial key in host cell for coronavirus infection.Journal of molecular cell biology · 2020Review
- Bacterial Pneumonia in Dogs and Cats: An Update.The Veterinary clinics of North America. Small animal practice · 2020Review
- Detection of selected viral pathogens in dogs with canine infectious respiratory disease in Austria.The Journal of small animal practice · 2019Article
- Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas.Transboundary and emerging diseases · 2019Article
- Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.Veterinary research · 2018Article
- Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4.Scientific reports · 2018Article
- European surveillance of emerging pathogens associated with canine infectious respiratory disease.Veterinary microbiology · 2017Article
- Detection of non-primate hepaciviruses in UK dogs.Virology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine infectious respiratory disease (CIRD) occurs frequently in densely housed dog populations. One of the common pathogens involved is canine respiratory coronavirus (CRCoV), however little is known regarding its pathogenesis and the role it plays in the development of CIRD. The pathogenesis of five geographically unrelated canine respiratory coronavirus (CRCoV) isolates was investigated. Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. The presence of CRCoV was associated with marked histopathological changes in the nares and trachea, with loss and damage to tracheal cilia, accompanied by inflammation. Viral shedding was readily detected from the oropharynx up to 10 days post infection, but there was little or no evidence of rectal shedding. The successful re-isolation of CRCoV from a wide range of respiratory and mucosal associated lymphoid tissues, and lung lavage fluids demonstrates a clear tropism of CRCoV for respiratory tissues and fulfils the final requirement for Koch's postulates. By study day 14 dogs had seroconverted to CRCoV and the antibodies raised were neutralising against both homologous and heterologous strains of CRCoV in vitro, thus demonstrating antigenic homogeneity among CRCoV strains from the two continents. Defining the role that CRCoV and other agents play in CIRD is a considerable, but important, challenge if the disease is to be managed, treated and prevented more successfully. Here we have successfully developed a model for studying the pathogenicity and the role of CRCoV in CIRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.