Evidence map›Paper›PMID 23279912›Full record

ArticleVirology journal2013

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines.

Maja Malkowska, Katarzyna Kokoszynska, Magdalena Dymecka, Leszek Rychlewski, Lucjan S Wyrwicz

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 245 citations in OpenAlex.

  1. Article
  2. The Structures and Functions of VZV Glycoproteins.Current topics in microbiology and immunology · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Chemokine Subversion by Human Herpesviruses.Journal of innate immunity · 2018
    Review
  7. Chemokines encoded by herpesviruses.Journal of leukocyte biology · 2017
    Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maja MalkowskaLaboratory of Bioinformatics and Biostatistics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, WK Roentgena 5, Warsaw, Poland. lucjan@bioinfo.pl
Katarzyna Kokoszynska
Magdalena Dymecka
Leszek Rychlewski
Lucjan S Wyrwicz
The Maria Sklodowska-Curie National Research Institute of Oncology · PLBioInfoBank Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.

Indexed as

AlphaherpesvirinaeAmino Acid SequenceBetaherpesvirinaeChemokinesEvolution, MolecularGammaherpesvirinaeModels, MolecularMolecular Sequence DataProtein ConformationSequence AlignmentViral Envelope ProteinsChemokinesViral Envelope Proteins

Identifiers

PMID23279912
PMCPMC3598415
OpenAlexW2109736846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.