Trial reportCNS neuroscience & therapeutics2013
Reduced frontal activation during a working memory task in mild cognitive impairment: a non-invasive near-infrared spectroscopy study.
Trial report in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional near-infrared spectroscopy for identifying mild cognitive impairment and Alzheimer's disease: a systematic review.Frontiers in neurology · 2025Pooled it
- Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis.Journal of medical Internet research · 2022Pooled it
- Examination of Variables That May Affect the Relationship Between Cognition and Functional Status in Individuals with Mild Cognitive Impairment: A Meta-Analysis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2016Pooled it
- Neural correlates of weight-shift training in older adults: a randomized controlled study.Scientific reports · 2023Trial
- Screening diagnosis of executive dysfunction after ischemic stroke and the effects of transcranial magnetic stimulation: A prospective functional near-infrared spectroscopy study.CNS neuroscience & therapeutics · 2023Trial
- Beta wave enhancement neurofeedback improves cognitive functions in patients with mild cognitive impairment: A preliminary pilot study.Medicine · 2019Trial
- Frontal haemodynamic responses in depression and the effect of electroconvulsive therapy.Journal of psychopharmacology (Oxford, England) · 2019Trial
- An interpretable deep learning diagnostic framework for early Alzheimer's disease based on EEG microstate spectra and multi-branch CNN.Journal of neuroengineering and rehabilitation · 2026Article
- Gut-brain health effects of PREbiotics in older adults with suspected COgnitive DEcline: design of the PRECODE randomised placebo-controlled trial.Frontiers in nutrition · 2026Article
- Impact of Anesthesia on Brain Functional Networks in Moyamoya Disease and Spinal Lesions.CNS neuroscience & therapeutics · 2025Article
- The Role of Near-Infrared Spectroscopy (NIRS) in Neurological and Neurodegenerative Diseases as Support to Clinical Practice: An Overview of the Literature.Diagnostics (Basel, Switzerland) · 2025Review
- Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study.BMC geriatrics · 2025Article
- An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment.Frontiers in neurology · 2025Article
- Article
- The Mixed Role of Sleep and Time of Day in Working Memory Performance of Older Adults with Mild Cognitive Impairment.Healthcare (Basel, Switzerland) · 2024Article
- Prefrontal cortex activation under stress as a function of borderline personality disorder in female adolescents engaging in non-suicidal self-injury.BJPsych open · 2024Article
- Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- fNIRS as a biomarker for individuals with subjective memory complaints and MCI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Exploring Aesthetic Perception in Impaired Aging: A Multimodal Brain-Computer Interface Study.Sensors (Basel, Switzerland) · 2024Article
- The Contribution of Functional Near-Infrared Spectroscopy (fNIRS) to the Study of Neurodegenerative Disorders: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWorking memory (WM) impairments are considered to be a main feature of mild cognitive impairment (MCI). Functional brain imaging studies have revealed evidence of alterations in the frontal and temporal cortices associated with WM in MCI patients. However, some imaging methods are too expensive for routine clinical use and have a low temporal resolution.
methodsUsing a newly developed near-infrared spectroscopy (NIRS) system, we studied the spatiotemporal dynamics of oxygenated hemoglobin (oxy-Hb) during a WM task in eight patients with mild cognitive impairment (MCI) and 16 age- and gender-matched healthy controls.
resultsWe performed temporal and spatial correlation analyses on each group during their WM tasks. These results consistently demonstrated that, when compared with the healthy controls, the MCI patients exhibited significantly decreased activation in the left frontal, right superior frontal and left temporal lobes. We found evidence of altered frontal and temporal processing during WM tasks in the MCI patients.
conclusionsThese results confirm the functional deficits in the frontal and temporal cortices and the impairment of WM and cognitive abilities in MCI patients and suggest that fNIRS may be a useful tool for evaluating brain activation in cognitive disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.