Evidence map›Paper›PMID 23279432›Full record

ReviewJournal of the peripheral nervous system : JPNS2012

Axonal transport disruption in peripheral nerve disease: From Jack's discoveries as a resident to recent contributions.

Thomas E Lloyd

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the peripheral nervous system : JPNS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thomas E LloydDepartment of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. tlloyd4@jhmi.edu.
Johns Hopkins Medicine · US

Funding

A Drosophila model of motor neuron disease using mutations in P150 / Dynactin.K08NS062890 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E. · 2008 to 2012
$878k
NINDS NIH HHS K08 NS062890
6 · The paper itself

Abstract

Many neurodegenerative diseases and neuropathies have been proposed to be caused by a disruption of axonal transport. However, the mechanisms whereby impaired transport causes disease remain unclear. Proposed mechanisms include impairment in delivery of organelles such as mitochondria, defective retrograde neurotrophic signaling, and disruption of the synaptic vesicle cycle within the synaptic terminal. Simple model organisms such as the fruitfly, Drosophila melanogaster, allow live imaging of axonal transport to be combined with high-throughput genetic screens and are providing insights into the pathophysiology of peripheral nerve diseases.

Indexed as

AnimalsAxonal TransportHumansPeripheral Nervous System Diseases

Identifiers

PMID23279432
PMCPMC4365469
OpenAlexW1588465554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.