ArticleDeveloping world bioethics2014
Ethical issues in field trials of genetically modified disease-resistant mosquitoes.
Article in Developing world bioethics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Trial
- Exploring the ethics of tuberculosis human challenge models.Journal of medical ethics · 2026Article
- Exploratory conversations with biodiversity-oriented civil society groups on the potential applications of gene drive-modified mosquitoes for malaria control in Tanzania.Transgenic research · 2026Article
- Maximizing horizontal transmission through mating: increased mating frequency and mating competitiveness associated with Microsporidia MB-infected Anopheles arabiensis males.Malaria journal · 2025Article
- Evaluating quasi-experimental approaches for estimating epidemiological efficacy of non-randomised field trials: applications in Wolbachia interventions for dengue.BMC medical research methodology · 2024Article
- Biosafety, biosecurity, and bioethics.Monash bioethics review · 2024Review
- Willingness to accept and participate in a Microsporidia MB-based mosquito release strategy: a community-based rapid assessment in western Kenya.Malaria journal · 2024Article
- The ethics of species extinctions.Cambridge prisms. Extinction · 2023Review
- Perspectives of vector management in the control and elimination of vector-borne zoonoses.Frontiers in microbiology · 2023Review
- Articulating ethical principles guiding Target Malaria's engagement strategy.Malaria journal · 2022Article
- Selection of sites for field trials of genetically engineered mosquitoes with gene drive.Evolutionary applications · 2021Article
- A Review:Vaccines · 2021Review
- "Drones are a great idea! What is an AED?" novel insights from a qualitative study on public perception of using drones to deliver automatic external defibrillators.Resuscitation plus · 2020Article
- Public health concerns over gene-drive mosquitoes: will future use of gene-drive snails for schistosomiasis control gain increased level of community acceptance?Pathogens and global health · 2020Review
- Two unresolved issues in community engagement for field trials of genetically modified mosquitoes.Pathogens and global health · 2019Article
- A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control.Acta tropica · 2018Article
- Ethics of community engagement in field trials of genetically modified mosquitoes.Developing world bioethics · 2018Article
- Towards inclusive social appraisal: risk, participation and democracy in governance of synthetic biology.BMC proceedings · 2018Review
- Teilhard de Chardin's oeuvre within an ongoing discussion of a gene drive release for public health reasons.Life sciences, society and policy · 2017Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Mosquito-borne diseases take a tremendous toll on human populations, especially in developing nations. In the last decade, scientists have developed mosquitoes that have been genetically modified to prevent transmission of mosquito-borne diseases, and field trials have been conducted. Some mosquitoes have been rendered infertile, some have been equipped with a vaccine they transmit to humans, and some have been designed to resist diseases. This article focuses on ethical issues raised by field trials of disease-resistant, genetically modified mosquitoes. Some of these issues include: protecting the public and the environment from harm, balancing benefits and risks, collaborating with the local community, avoiding exploitation, and safeguarding the rights and welfare of research subjects. One of the most difficult problems involves protecting the welfare of community members who will be impacted by the release of mosquitoes but who are not enrolled in the study as research subjects. To address this concern, field trials should take place only when the targeted disease is a significant public health problem in an isolated area, the benefits of the trial for the community are likely to outweigh the risks, community leaders approve of the trial, and there are measures in place to protect the welfare of un-enrolled community members, such as informing the community about the study and offering free treatment to people who contract mosquito-borne diseases. Since the justification of any field trial depends on a careful examination of the scientific and ethical issues, proposed studies should be evaluated on a case-by-case basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.