ArticleExperimental dermatology2013
Skewed distribution of natural killer cells in psoriasis skin lesions.
Article in Experimental dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ.Frontiers in immunology · 2025Review
- Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer.Microorganisms · 2024Review
- A Transcriptome-Wide Analysis of Psoriasis: Identifying the Potential Causal Genes and Drug Candidates.International journal of molecular sciences · 2023Article
- Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications.Archivum immunologiae et therapiae experimentalis · 2023Review
- The influence of a biofilm-dispersing wound gel on the wound healing process.International wound journal · 2022Article
- Current Concepts of Psoriasis Immunopathogenesis.International journal of molecular sciences · 2021Review
- Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection.Scientific reports · 2020Article
- Innate Lymphocytes in Psoriasis.Frontiers in immunology · 2020Review
- Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.The Journal of investigative dermatology · 2018Article
- A Task Force Against Local Inflammation and Cancer: Lymphocyte Trafficking to and Within the Skin.Frontiers in immunology · 2018Review
- Establishment and function of tissue-resident innate lymphoid cells in the skin.Protein & cell · 2017Review
- The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.Current diabetes reports · 2016Review
- Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.Human genetics · 2016Article
- CD57 in human natural killer cells and T-lymphocytes.Cancer immunology, immunotherapy : CII · 2016Review
- Phenotype and functions of conventional and non-conventional NK cells.Current opinion in immunology · 2016Review
- Tumor necrosis factor superfamily in innate immunity and inflammation.Cold Spring Harbor perspectives in biology · 2014Review
- Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.BMC medical genomics · 2014Article
- NK cell autoreactivity and autoimmune diseases.Frontiers in immunology · 2014Review
- Organ-specific phenotypic and functional features of NK cells in humans.Immunologic research · 2014Review
- Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease.Frontiers in immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Psoriasis is a hyper-proliferative disease of the skin in which immunological mechanisms play a direct pathogenetic role. There have been limited studies of natural killer (NK) cells in psoriasis. The aim of this study was to examine the phenotype of NK cells in skin biopsies and peripheral blood mononuclear cells from patients with psoriasis and healthy controls. CD56(+) CD16(-) and CD56(+) CD16(+) NK cells were isolated from lesional skin, unaffected skin and PBMC of psoriasis patients, and normal skin and PBMC from healthy controls. The expression of CD57, NKG2A and NKG2C was assessed by flow cytometry. NK cells in psoriasis skin lesions were skewed in their expression of CD57, a marker of NK cell maturity, with CD57 expression significantly reduced and NKG2A expression increased on NK cells in lesional and unaffected skin compared to controls. These data suggest that in this patient cohort, NK cells could be isolated from psoriasis lesions and exhibit an immature phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.