ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2013
Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 47 citations in OpenAlex.
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- Patterns of allergic sensitization and factors associated with emergence of sensitization in the rural tropics early in the life course: findings of an Ecuadorian birth cohort.Frontiers in allergy · 2021Article
- Identification and Physicochemical Characterization of a New Allergen fromInternational journal of molecular sciences · 2020Article
- Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city.PloS one · 2020Article
- Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran.Infection · 2019Article
- Worms: Pernicious parasites or allies against allergies?Parasite immunology · 2019Review
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- Classification of Wheezing Children in Rural Bangladesh by Intensity ofJournal of immunology research · 2019Article
- Is childhood wheeze and asthma in Latin America associated with poor hygiene and infection? A systematic review.BMJ open respiratory research · 2018Article
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- Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice.European clinical respiratory journal · 2017Review
- A life without worms.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2017Review
- Evolution of Socioeconomic Conditions and Its Relation to Spatial-Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children.EcoHealth · 2016Article
- Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond.The American journal of tropical medicine and hygiene · 2016Review
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- Role in Allergic Diseases of Immunological Cross-Reactivity between Allergens and Homologues of Parasite Proteins.Critical reviews in immunology · 2016Review
- Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador.International journal of epidemiology · 2015Article
- Asthma in Latin America.Thorax · 2015Review
- Risk factors for acute asthma in tropical America: a case-control study in the City of Esmeraldas, Ecuador.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundMost childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age.
objectiveTo explore the effects of geohelminth infections and age on atopy, wheeze, and the association between atopy and wheeze.
methodsA case-control study was done in 376 subjects (149 cases and 227 controls) aged 7-19 years living in rural communities in Ecuador. Wheeze cases, identified from a large cross-sectional survey, had recent wheeze and controls were a random sample of those without wheeze. Atopy was measured by the presence of allergen-specific IgE (asIgE) and skin prick test (SPT) responses to house dust mite and cockroach. Geohelminth infections were measured in stools and anti-Ascaris IgE in plasma.
resultsThe fraction of recent wheeze attributable to anti-Ascaris IgE was 45.9%, while those for SPT and asIgE were 10.0% and 10.5% respectively. The association between atopy and wheeze was greater in adolescents than children. Although Anti-Ascaris IgE was strongly associated with wheeze (adj. OR 2.24 (95% CI 1.33-3.78, P = 0.003) and with asIgE (adj. OR 5.34, 95% CI 2.49-11.45, P < 0.001), the association with wheeze was independent of asIgE. There was some evidence that the association between atopy and wheeze was greater in uninfected subjects compared with those with active geohelminth infections. CONCLUSIONS AND CLINICAL RELEVANCE: Atopy to house dust mite and cockroach explained few wheeze cases in our study population, while the presence of anti-Ascaris IgE was an important risk factor. Our data provided only limited evidence that active geohelminth infections attenuated the association between atopy and wheeze in endemic areas or that age modified this association. The role of allergic sensitization to Ascaris in the development of wheeze, independent of atopy, requires further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.