ArticleClinical transplantation
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection.
Article in Clinical transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A Mini-Review of Adverse Lung Transplant Outcomes Associated With Respiratory Viruses.Frontiers in immunology · 2019Pooled it
- Clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2022Observational
- Donor derived cell free DNA% is elevated with pathogens that are risk factors for acute and chronic lung allograft injury.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Rapid molecular detection of airway pathogens in lung transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2021Observational
- Epidemiology and persistence of rhinovirus in pediatric lung transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2020Observational
- Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.BMC infectious diseases · 2020Article
- A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection.Journal of the Pediatric Infectious Diseases Society · 2019Observational
- Coronavirus and Chronic Lung Allograft Dysfunction: Hiding in Plain Sight?Transplantation direct · 2018Article
- Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017Article
- Article
- Graft Loss and CLAD-Onset Is Hastened by Viral Pneumonia After Lung Transplantation.Transplantation · 2016Article
- Infectious Triggers of Chronic Lung Allograft Dysfunction.Current infectious disease reports · 2016Review
- Respiratory Syncytial Virus in Hematopoietic Stem Cell Transplantation and Solid-Organ Transplantation.Current infectious disease reports · 2015Article
- Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction.Journal of inflammation research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCommunity acquired respiratory virus (CARV) infections in lung transplant recipients (LTR) have been associated with adverse outcomes, including acute rejection (AR) and decline in allograft function, in some but not in all studies.
methodsSpirometry and transbronchial biopsy results of LTR diagnosed with CARV infection over a two-yr period were extracted from clinical records. Primary outcomes, studied at 1-2.5 months postinfection, were as follows: (i) incidence of biopsy-proven AR (grade >A0) and (ii) allograft function, defined by forced expiratory volume in one s (FEV(1)). A reference group of biopsies (n = 526) collected during the study period established the baseline incidence of AR. Rhinovirus (RV) and non-rhinovirus (non-RV) infections were analyzed as subgroups.
resultsEighty-seven cases of CARV infection were identified in 59 subjects. Incidences of AR were similar in the post-CARV and reference groups and did not differ significantly after RV vs. non-RV infection. Allograft function declined significantly after non-RV infection, but not after RV infection.
conclusionsIn LTR, CARV infections other than RV are associated with allograft dysfunction at 1-2.5 months after infection. However, CARVs do not appear associated with AR at this time point. The impact of specific CARVs on lung allografts, including the development of chronic allograft rejection, merits further study.
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