ArticleAnnals of human genetics2013
A small number of candidate gene SNPs reveal continental ancestry in African Americans.
Article in Annals of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Including diverse and admixed populations in genetic epidemiology research.Genetic epidemiology · 2022Article
- Population genetics of wild Macaca fascicularis with low-coverage shotgun sequencing of museum specimens.American journal of physical anthropology · 2020Article
- Population Stratification in Genetic Association Studies.Current protocols in human genetics · 2017Review
- Ancestry inference using principal component analysis and spatial analysis: a distance-based analysis to account for population substructure.BMC genomics · 2017Article
- Genetic African Ancestry and Markers of Mineral Metabolism in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data.Frontiers in genetics · 2016Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Using genetic data from an obesity candidate gene study of self-reported African Americans and European Americans, we investigated the number of Ancestry Informative Markers (AIMs) and candidate gene SNPs necessary to infer continental ancestry. Proportions of African and European ancestry were assessed with STRUCTURE (K = 2), using 276 AIMs. These reference values were compared to estimates derived using 120, 60, 30, and 15 SNP subsets randomly chosen from the 276 AIMs and from 1144 SNPs in 44 candidate genes. All subsets generated estimates of ancestry consistent with the reference estimates, with mean correlations greater than 0.99 for all subsets of AIMs, and mean correlations of 0.99 ± 0.003; 0.98 ± 0.01; 0.93 ± 0.03; and 0.81 ± 0.11 for subsets of 120, 60, 30, and 15 candidate gene SNPs, respectively. Among African Americans, the median absolute difference from reference African ancestry values ranged from 0.01 to 0.03 for the four AIMs subsets and from 0.03 to 0.09 for the four candidate gene SNP subsets. Furthermore, YRI/CEU Fst values provided a metric to predict the performance of candidate gene SNPs. Our results demonstrate that a small number of SNPs randomly selected from candidate genes can be used to estimate admixture proportions in African Americans reliably.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.