ArticleAntimicrobial agents and chemotherapy1990
Successful treatment using gentamicin liposomes of Salmonella dublin infections in mice.
Article in Antimicrobial agents and chemotherapy, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections.Pharmaceutical research · 2022Pooled it
- Liposomal Formulations: A Recent Update.Pharmaceutics · 2024Review
- Article
- Bioactive metabolites ofFrontiers in cellular and infection microbiology · 2023Article
- Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases.Molecular pharmaceutics · 2012Review
- The Role of the spv Genes in Salmonella Pathogenesis.Frontiers in microbiology · 2011Article
- WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study.BMJ (Clinical research ed.) · 2010Article
- Genetic requirements for salmonella-induced cytopathology in human monocyte-derived macrophages.Infection and immunity · 2002Article
- Comparative efficacies of liposomal amikacin (MiKasome) plus oxacillin versus conventional amikacin plus oxacillin in experimental endocarditis induced by Staphylococcus aureus: microbiological and echocardiographic analyses.Antimicrobial agents and chemotherapy · 1999Article
- Intracellular delivery and antibacterial activity of gentamicin encapsulated in pH-sensitive liposomes.Antimicrobial agents and chemotherapy · 1998Article
- The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host.Infection and immunity · 1997Article
- Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells.Infection and immunity · 1996Article
- In vitro binding of the Salmonella dublin virulence plasmid regulatory protein SpvR to the promoter regions of spvA and spvR.Journal of bacteriology · 1996Article
- Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells.Infection and immunity · 1993Article
- Liposome-incorporated ciprofloxacin in treatment of murine salmonellosis.Antimicrobial agents and chemotherapy · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All mice survived after treatment with a single i.v. or intraperitoneal injection of 20 mg of gentamicin liposomes per kg, whereas that dose of free drug was completely ineffective and caused neuromuscular paralysis when injected rapidly i.v. In mice treated with gentamicin liposomes, there was a steady decrease in the number of salmonellae in spleens for 2 weeks after treatment. High concentrations of gentamicin were present in the spleen for at least 10 days after treatment. Although gentamicin was not detected in the mesenteric lymph nodes of mice treated with gentamicin liposomes, bacterial counts in the nodes also decreased over time. Small numbers of bacteria remained viable in the mesenteric lymph nodes and Peyer's patches but not in the spleens of mice treated with 20 to 80 mg/kg. Mice treated with doses of gentamicin liposomes as high as 80 mg/kg showed only a transient increase in blood urea nitrogen and no rise in serum creatinine. These results confirm that gentamicin in liposomes is less toxic in mice than is free gentamicin and is extremely effective therapy for disseminated Salmonella infections in mice.
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