ArticleJournal of biological physics2012
Understanding the role of hydrogen bonds in water dynamics and protein stability.
Article in Journal of biological physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Unravelling Water Anomalies Using a Percolation Approach.ACS omega · 2026Article
- Spatial Extent and Heterogeneity of Water at Phospholipid Membranes Revealed by Molecular Dynamics.Sub-cellular biochemistry · 2026Review
- Structural Modelling of Krüppel-Like Factor 15 Zinc Finger Binding Domain to DNA Using AlphaFold 3.0: Potential Therapeutic Target for Type 2 Diabetes.Journal of cellular and molecular medicine · 2025Article
- Hydrophobic Homopolymer's Coil-Globule Transition and Adsorption onto a Hydrophobic Surface under Different Conditions.The journal of physical chemistry. B · 2023Article
- Structure and activity of a thermally stable mutant of Acanthamoeba actophorin.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Thermal tuning of protein hydration in a hyperthermophilic enzyme.Frontiers in molecular biosciences · 2022Article
- Advances in the study of supercooled water.The European physical journal. E, Soft matter · 2021Review
- Review
- Article
- Role of cavities and hydration in the pressure unfolding of T4 lysozyme.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Critical behavior of a water monolayer under hydrophobic confinement.Scientific reports · 2014Article
- A facile process for soak-and-peel delamination of CVD graphene from substrates using water.Scientific reports · 2014Article
- Carbohydrate recognition by RpfB from Mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of cold and pressure denaturation of proteins are a matter of debate, but it is commonly accepted that water plays a fundamental role in the process. It has been proposed that the denaturation process is related to an increase of hydrogen bonds among hydration water molecules. Other theories suggest that the causes of denaturation are the density fluctuations of surface water, or the destabilization of hydrophobic contacts as a consequence of water molecule inclusions inside the protein, especially at high pressures. We review some theories that have been proposed to give insight into this problem, and we describe a coarse-grained model of water that compares well with experiments for proteins' hydration water. We introduce its extension for a homopolymer in contact with the water monolayer and study it by Monte Carlo simulations in an attempt to understand how the interplay of water cooperativity and interfacial hydrogen bonds affects protein stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.