ArticleJournal of biological physics2012
Water in the orchestration of the cell machinery. Some misunderstandings: a short review.
Article in Journal of biological physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
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- Liquid-Liquid Phase Separation from the Viewpoint of Molecular Crowding Environment: A Raman Imaging Study.The journal of physical chemistry. B · 2025Review
- Epistemological implications of astroglia scientific research.Frontiers in cellular neuroscience · 2025Article
- Molecular Crowding: Physiologic Sensing and Control.Annual review of physiology · 2024Review
- Microfluidics delivery of DARPP-32 into HeLa cells maintains viability for in-cell NMR spectroscopy.Communications biology · 2022Article
- Increase in the Intracellular Bulk Water Content in the Early Phase of Cell Death of Keratinocytes, Corneoptosis, as Revealed by 65 GHz Near-Field CMOS Dielectric Sensor.Molecules (Basel, Switzerland) · 2022Article
- Electromagnetic interactions in regulations of cell behaviors and morphogenesis.Frontiers in cell and developmental biology · 2022Review
- On the Dependence of Prion and Amyloid Structure on the Folding Environment.International journal of molecular sciences · 2021Article
- Novel insights in linking solvent relaxation dynamics and protein conformations utilizing red edge excitation shift approach.Emerging topics in life sciences · 2021Review
- Rapid differentiation of human dental pulp stem cells to neuron-like cells by high KBiophysics and physicobiology · 2020Article
- Green Rust: The Simple Organizing 'Seed' of All Life?Life (Basel, Switzerland) · 2018Review
- Water in the human body: An anesthesiologist's perspective on the connection between physicochemical properties of water and physiologic relevance.Annals of medicine and surgery (2012) · 2018Review
- Article
- Thermodynamic implications of high Q 10 of thermo-TRP channels in living cells.Biophysics (Nagoya-shi, Japan) · 2015Article
- Blind prediction of interfacial water positions in CAPRI.Proteins · 2014Article
- Changes to cellular water and element content induced by nucleolar stress: investigation by a cryo-correlative nano-imaging approach.Cellular and molecular life sciences : CMLS · 2013Article
- Physical aspects of sensory transduction on seeing, hearing and smelling.Biophysics (Nagoya-shi, Japan) · 2013Review
- A dynamic role for water in biological systems.Journal of biological physics · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, biologists can explore the cell at the nanometre level. They discover an unsuspected world, amazingly overcrowded, complex and heterogeneous, in which water, also, is complex and heterogeneous. In the cell, statistical phenomena, such as diffusion, long considered as the main transport for water soluble substances, must be henceforth considered as inoperative to orchestrate cell activity. Results at this level are not yet numerous enough to give an exact representation of the cell machinery; however, they are sufficient to cease reasoning in terms of statistics (diffusion, law of mass action, pH, etc.) and encourage cytologists and biochemists to prospect thoroughly the huge panoply of the biophysical properties of macromolecule-water associations at the nanometre level. Our main purpose, here, is to discuss some of the more common misinterpretations due to the ignorance of these properties, and expose briefly the bases for a better approach of the cell machinery. Giorgio Careri, who demonstrated the correlation between proton currents at the surface of lysozyme and activity of this enzyme was one of the pioneers of this approach.
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